C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NIMA (never in mitosis gene a)-related expressed kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026622 Nek2 10090 + 1:191821444-191833050 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027931 Nek2-001 191821444-191833050 protein_coding
  ENSMUST00000126446 Nek2-002 191821510-191828292 retained_intron
  ENSMUST00000136733 Nek2-004 191827148-191829988 processed_transcript
  ENSMUST00000150839 Nek2-003 191822182-191825825 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027931ENSMUST00000126446ENSMUST00000136733ENSMUST00000150839
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027931 0.987±0.51 0.627±0.13 0.428±0.02 2.747±0.97 0.399±0.17 2.700±0.87 0.163±0.05 0.302±0.11 6.173±6.82 1.132±0.53 0.090±0.04 2.939±1.12 9.846±6.40 48.421±21.14
ENSMUST00000126446 N/A N/A N/A 0.595±0.00 0.146±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000136733 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.351±0.00 11.509±0.00 19.850±18.42 178.695±0.00
ENSMUST00000150839 N/A N/A N/A N/A N/A N/A 0.106±0.04 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00041V CIL_00041V_0002 CGP 1:191717834-191833050
CIL_00042A CIL_00042A_0002 CGP 1:191821444-191913247

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000070 IMP mitotic sister chromatid segregation
GO:0000776 IEA kinetochore
GO:0000794 IDA condensed nuclear chromosome
GO:0000922 IDA spindle pole
GO:0001824 IMP blastocyst development
GO:0004672 IDA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005813 IEA centrosome
GO:0005874 IEA microtubule
GO:0006468 IDA protein phosphorylation
GO:0007059 IMP chromosome segregation
GO:0019903 IEA protein phosphatase binding
GO:0030496 IDA midbody
GO:0043234 IEA protein complex
GO:0043392 IDA negative regulation of DNA binding
GO:0045171 IEA intercellular bridge
GO:0046777 ISS protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0051299 IEA centrosome separation
GO:0051321 IEA meiotic cell cycle
GO:0051988 ISS regulation of attachment of spindle microtubules to kinetochore
GO:0090307 IMP spindle assembly involved in mitosis
GO:1903126 IEA negative regulation of centriole-centriole cohesion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005619 nek2 NIMA (never in mitosis gene a)-related kinase 2 protein_coding Danio_rerio
ENSG00000117650 NEK2 NIMA-related kinase 2 protein_coding Homo_sapiens

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