C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000119689 DLST 9606 + 14:74881891-74903745 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000238671 DLST-004 74881916-74902452 nonsense_mediated_decay
  ENST00000334220 DLST-001 74881893-74903745 protein_coding
  ENST00000550473 DLST-015 74889069-74889669 retained_intron
  ENST00000554612 DLST-002 74881915-74902551 nonsense_mediated_decay
  ENST00000554806 DLST-006 74881956-74898486 protein_coding
  ENST00000555071 DLST-003 74881922-74892058 retained_intron
  ENST00000555089 DLST-005 74881941-74901190 nonsense_mediated_decay
  ENST00000555190 DLST-013 74881925-74898455 processed_transcript
  ENST00000555459 DLST-012 74881925-74891350 retained_intron
  ENST00000555492 DLST-008 74881903-74892943 nonsense_mediated_decay
  ENST00000555988 DLST-014 74885586-74894409 nonsense_mediated_decay
  ENST00000556190 DLST-011 74881925-74886024 retained_intron
  ENST00000556460 DLST-007 74881891-74892947 nonsense_mediated_decay
  ENST00000556582 DLST-010 74881916-74891289 retained_intron
  ENST00000557012 DLST-009 74881914-74889733 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000238671ENST00000334220ENST00000555071ENST00000555089
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000238671 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.994±0.00 N/A
ENST00000334220 4.017±0.00 4.531±0.00 7.774±0.00 1.021±0.00 3.293±1.62 7.214±0.00 8.431±1.75 10.200±0.00 2.932±0.25 2.713±0.00 3.220±0.00 14.753±7.34 21.329±4.47 3.810±0.00
ENST00000555071 N/A N/A N/A N/A N/A N/A N/A N/A 2.933±0.00 N/A N/A N/A N/A N/A
ENST00000555089 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.307±0.00 7.497±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004KC CIL_0004KC_0002 CGP 14:74852871-74903745
CIL_0004K5 CIL_0004K5_0002 CGP 14:74881891-74923396

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004149 IEA dihydrolipoyllysine-residue succinyltransferase activity
GO:0005634 IDA nucleus
GO:0005739 IEA mitochondrion
GO:0005759 TAS mitochondrial matrix
GO:0006091 TAS generation of precursor metabolites and energy
GO:0006099 TAS:IEA tricarboxylic acid cycle
GO:0006554 TAS lysine catabolic process
GO:0008152 IEA metabolic process
GO:0016020 IDA membrane
GO:0016740 IEA transferase activity
GO:0016746 IEA transferase activity, transferring acyl groups
GO:0033512 IEA L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0044237 TAS cellular metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045252 IEA oxoglutarate dehydrogenase complex
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014230 dlst dihydrolipoamide S-succinyltransferase protein_coding Danio_rerio
ENSMUSG00000004789 Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) protein_coding Mus_musculus

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