C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transforming growth factor, beta 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000119699 TGFB3 9606 - 14:75958099-75982991 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000238682 TGFB3-001 75958202-75981191 protein_coding
  ENST00000554980 TGFB3-003 75958099-75966722 retained_intron
  ENST00000555193 TGFB3-006 75980576-75982836 processed_transcript
  ENST00000556285 TGFB3-002 75963062-75980993 protein_coding
  ENST00000556507 TGFB3-004 75959289-75960957 processed_transcript
  ENST00000556674 TGFB3-005 75981243-75982991 processed_transcript
  ENST00000557493 TGFB3-007 75960861-75970790 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000238682ENST00000554980ENST00000555193ENST00000556674
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000238682 3.325±0.00 16.676±0.00 N/A 4.578±3.91 3.754±1.50 3.961±3.46 2.946±0.00 4.117±0.00 1.989±1.16 15.005±14.08 5.456±4.57 2.368±0.72 9.781±2.59 9.429±6.50
ENST00000554980 N/A N/A 0.275±0.00 0.408±0.00 0.977±0.00 N/A 0.345±0.00 N/A N/A N/A N/A 0.781±0.00 N/A 0.680±0.00
ENST00000555193 N/A N/A N/A 2.009±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000556674 2.847±0.00 N/A N/A 11.247±0.00 4.509±0.00 0.690±0.00 N/A N/A N/A N/A N/A 0.995±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0001666 IDA response to hypoxia
GO:0001701 ISS in utero embryonic development
GO:0002576 TAS platelet degranulation
GO:0005114 IDA type II transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IEA extracellular space
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005886 IC plasma membrane
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007184 IEA SMAD protein import into nucleus
GO:0007435 IEP salivary gland morphogenesis
GO:0007565 IEA female pregnancy
GO:0007568 IEA aging
GO:0007596 TAS blood coagulation
GO:0008083 IEA growth factor activity
GO:0008156 IMP negative regulation of DNA replication
GO:0008285 ISS negative regulation of cell proliferation
GO:0009887 IEA organ morphogenesis
GO:0009986 IEA cell surface
GO:0010718 ISS positive regulation of epithelial to mesenchymal transition
GO:0010862 ISS positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 IDA negative regulation of macrophage cytokine production
GO:0016049 IEA cell growth
GO:0022601 IEP menstrual cycle phase
GO:0030141 IEA secretory granule
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030315 IEA T-tubule
GO:0030501 IEP positive regulation of bone mineralization
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030879 ISS mammary gland development
GO:0031012 IDA extracellular matrix
GO:0031093 TAS platelet alpha granule lumen
GO:0032570 IDA response to progesterone
GO:0032967 IMP positive regulation of collagen biosynthetic process
GO:0034616 IEA response to laminar fluid shear stress
GO:0034713 IDA type I transforming growth factor beta receptor binding
GO:0040007 IEA growth
GO:0042060 IEA wound healing
GO:0042476 NAS odontogenesis
GO:0042802 IDA identical protein binding
GO:0043025 IEA neuronal cell body
GO:0043065 ISS positive regulation of apoptotic process
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043627 IEA response to estrogen
GO:0043932 IEP ossification involved in bone remodeling
GO:0045216 IDA cell-cell junction organization
GO:0045740 IMP positive regulation of DNA replication
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0048286 ISS lung alveolus development
GO:0048565 IEA digestive tract development
GO:0048702 IEA embryonic neurocranium morphogenesis
GO:0048839 IEA inner ear development
GO:0050431 IDA transforming growth factor beta binding
GO:0050714 IDA positive regulation of protein secretion
GO:0051491 ISS positive regulation of filopodium assembly
GO:0051781 IEA positive regulation of cell division
GO:0060021 ISS palate development
GO:0060325 IMP face morphogenesis
GO:0060364 IEA frontal suture morphogenesis
GO:0060391 ISS positive regulation of SMAD protein import into nucleus
GO:0070483 IDA detection of hypoxia
GO:0071363 IEA cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019367 tgfb3 transforming growth factor, beta 3 protein_coding Danio_rerio
ENSMUSG00000021253 Tgfb3 transforming growth factor, beta 3 protein_coding Mus_musculus

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