C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein tyrosine kinase 2 beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000120899 PTK2B 9606 + 8:27311482-27459391 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000346049 PTK2B-001 27325479-27459386 protein_coding
  ENST00000397497 PTK2B-003 27430899-27452559 protein_coding
  ENST00000397501 PTK2B-009 27311482-27459390 protein_coding
  ENST00000412793 PTK2B-007 27380651-27430388 protein_coding
  ENST00000420218 PTK2B-201 27325564-27459391 protein_coding
  ENST00000461615 PTK2B-006 27432103-27434522 retained_intron
  ENST00000482543 PTK2B-004 27452857-27454587 retained_intron
  ENST00000495097 PTK2B-005 27437455-27437992 retained_intron
  ENST00000496920 PTK2B-008 27380654-27396295 processed_transcript
  ENST00000517339 PTK2B-002 27397452-27459386 protein_coding
  ENST00000519512 PTK2B-011 27430887-27436308 protein_coding
  ENST00000519650 PTK2B-013 27311567-27322817 processed_transcript
  ENST00000521000 PTK2B-016 27422276-27431206 retained_intron
  ENST00000521164 PTK2B-014 27325345-27420001 protein_coding
  ENST00000522245 PTK2B-017 27454031-27458474 retained_intron
  ENST00000522338 PTK2B-010 27311629-27397789 protein_coding
  ENST00000522517 PTK2B-015 27326823-27422385 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000346049ENST00000397497ENST00000397501ENST00000412793ENST00000420218ENST00000517339ENST00000519650ENST00000521164ENST00000522517
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000346049 1.278±0.00 N/A N/A 19.151±10.27 3.528±0.00 1.839±0.08 1.780±0.00 3.392±0.00 1.312±0.00 4.536±1.34 0.528±0.00 1.767±0.19 5.531±2.47 2.061±0.00
ENST00000397497 N/A N/A N/A N/A 0.784±0.00 N/A N/A N/A 0.398±0.00 N/A N/A N/A N/A N/A
ENST00000397501 N/A N/A 0.969±0.00 N/A 0.602±0.00 0.573±0.00 N/A 0.482±0.00 0.988±0.10 N/A 0.976±0.00 N/A N/A 1.283±0.00
ENST00000412793 N/A N/A N/A N/A 3.256±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000420218 2.751±0.00 15.719±0.00 N/A 9.103±0.00 1.158±0.00 N/A 0.816±0.00 2.240±0.00 N/A N/A N/A 1.288±0.00 2.742±0.35 N/A
ENST00000517339 N/A N/A N/A N/A 2.577±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000519650 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.184±0.00 N/A N/A N/A
ENST00000521164 N/A N/A N/A N/A N/A 7.844±0.00 1.323±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000522517 N/A N/A N/A N/A N/A N/A 0.627±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000302 IEA response to reactive oxygen species
GO:0001525 IEA angiogenesis
GO:0001556 IEA oocyte maturation
GO:0001666 IEA response to hypoxia
GO:0001954 IMP positive regulation of cell-matrix adhesion
GO:0002040 ISS sprouting angiogenesis
GO:0002315 ISS marginal zone B cell differentiation
GO:0004672 IEA protein kinase activity
GO:0004683 ISS calmodulin-dependent protein kinase activity
GO:0004713 TAS:IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0004871 NAS:IEA signal transducer activity
GO:0004972 ISS N-methyl-D-aspartate selective glutamate receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005925 IDA:IEA focal adhesion
GO:0005938 IEA cell cortex
GO:0006461 TAS protein complex assembly
GO:0006468 TAS:IEA protein phosphorylation
GO:0006915 TAS apoptotic process
GO:0006950 TAS response to stress
GO:0006968 ISS cellular defense response
GO:0006970 IEA response to osmotic stress
GO:0007015 IEA actin filament organization
GO:0007155 IEA cell adhesion
GO:0007165 TAS signal transduction
GO:0007166 IMP cell surface receptor signaling pathway
GO:0007172 IEA signal complex assembly
GO:0007173 IEA epidermal growth factor receptor signaling pathway
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007229 IMP integrin-mediated signaling pathway
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0008360 IMP regulation of cell shape
GO:0009612 IEA response to mechanical stimulus
GO:0009725 IEA response to hormone
GO:0009749 IEA response to glucose
GO:0010226 IEA response to lithium ion
GO:0010243 IEA response to organonitrogen compound
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0010656 IEA negative regulation of muscle cell apoptotic process
GO:0010752 IEA regulation of cGMP-mediated signaling
GO:0010758 ISS regulation of macrophage chemotaxis
GO:0010976 IMP positive regulation of neuron projection development
GO:0014009 IEA glial cell proliferation
GO:0014069 ISS postsynaptic density
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017146 ISS N-methyl-D-aspartate selective glutamate receptor complex
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0030027 IDA lamellipodium
GO:0030154 IEA cell differentiation
GO:0030155 IMP regulation of cell adhesion
GO:0030279 IEA negative regulation of ossification
GO:0030307 IEA positive regulation of cell growth
GO:0030335 IMP positive regulation of cell migration
GO:0030424 IEA axon
GO:0030425 ISS dendrite
GO:0030426 ISS growth cone
GO:0030502 ISS negative regulation of bone mineralization
GO:0030826 IEA regulation of cGMP biosynthetic process
GO:0030838 IMP positive regulation of actin filament polymerization
GO:0031175 IEA neuron projection development
GO:0032403 IEA protein complex binding
GO:0032863 IEA activation of Rac GTPase activity
GO:0032960 ISS regulation of inositol trisphosphate biosynthetic process
GO:0033209 IMP tumor necrosis factor-mediated signaling pathway
GO:0035235 ISS ionotropic glutamate receptor signaling pathway
GO:0035902 IEA response to immobilization stress
GO:0038083 ISS peptidyl-tyrosine autophosphorylation
GO:0042220 IEA response to cocaine
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0042976 IMP activation of Janus kinase activity
GO:0043025 ISS neuronal cell body
GO:0043066 IMP negative regulation of apoptotic process
GO:0043149 IEA stress fiber assembly
GO:0043267 IDA negative regulation of potassium ion transport
GO:0043423 IEA 3-phosphoinositide-dependent protein kinase binding
GO:0043507 IEA positive regulation of JUN kinase activity
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043534 IEA blood vessel endothelial cell migration
GO:0043552 ISS positive regulation of phosphatidylinositol 3-kinase activity
GO:0044297 ISS cell body
GO:0045121 IEA membrane raft
GO:0045428 IEA regulation of nitric oxide biosynthetic process
GO:0045453 ISS bone resorption
GO:0045471 IEA response to ethanol
GO:0045638 IMP negative regulation of myeloid cell differentiation
GO:0045727 IEA positive regulation of translation
GO:0045766 IEA positive regulation of angiogenesis
GO:0045860 IMP positive regulation of protein kinase activity
GO:0046330 IMP positive regulation of JNK cascade
GO:0046777 TAS protein autophosphorylation
GO:0048010 IMP vascular endothelial growth factor receptor signaling pathway
GO:0048041 IEA focal adhesion assembly
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050848 IEA regulation of calcium-mediated signaling
GO:0051000 IEA positive regulation of nitric-oxide synthase activity
GO:0051279 ISS regulation of release of sequestered calcium ion into cytosol
GO:0051591 IEA response to cAMP
GO:0051592 IEA response to calcium ion
GO:0051968 ISS positive regulation of synaptic transmission, glutamatergic
GO:0060291 ISS long-term synaptic potentiation
GO:0070098 ISS chemokine-mediated signaling pathway
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0071300 IMP cellular response to retinoic acid
GO:0097440 ISS apical dendrite
GO:2000058 IDA regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000060 IEA positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000114 ISS regulation of establishment of cell polarity
GO:2000249 ISS regulation of actin cytoskeleton reorganization
GO:2000310 ISS regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000379 IEA positive regulation of reactive oxygen species metabolic process
GO:2000463 ISS positive regulation of excitatory postsynaptic membrane potential
GO:2000538 ISS positive regulation of B cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022841 ptk2ba protein tyrosine kinase 2 beta, a protein_coding Danio_rerio
ENSDARG00000039577 ptk2bb protein tyrosine kinase 2 beta, b protein_coding Danio_rerio
ENSMUSG00000059456 Ptk2b PTK2 protein tyrosine kinase 2 beta protein_coding Mus_musculus

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