C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: epiregulin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000124882 EREG 9606 + 4:74365143-74388751 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000244869 EREG-001 74365143-74388751 protein_coding
  ENST00000503689 EREG-003 74382423-74384952 processed_transcript
  ENST00000507603 EREG-002 74365173-74382013 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000244869ENST00000503689ENST00000507603
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000244869 N/A 0.128±0.00 0.031±0.00 N/A 0.297±0.03 0.176±0.00 0.021±0.01 0.041±0.00 0.584±0.00 0.010±0.00 0.895±0.54 0.174±0.13 0.041±0.00
ENST00000503689 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.178±0.00 0.107±0.00 N/A
ENST00000507603 0.318±0.00 0.274±0.00 0.246±0.00 0.148±0.00 0.268±0.00 N/A 0.171±0.00 0.235±0.00 0.492±0.00 0.088±0.00 0.047±0.00 0.051±0.00 0.348±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006SO CIL_0006SO_0001 CGP 4:74308473-74388751
CIL_000364 CIL_000364_0001 CGP 4:74365143-74455009

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001550 ISS ovarian cumulus expansion
GO:0001556 ISS oocyte maturation
GO:0001819 ISS positive regulation of cytokine production
GO:0005154 ISS epidermal growth factor receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005887 TAS integral component of plasma membrane
GO:0007143 ISS female meiotic division
GO:0007173 ISS epidermal growth factor receptor signaling pathway
GO:0007267 IDA cell-cell signaling
GO:0008083 IEA growth factor activity
GO:0008284 ISS positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009299 IDA mRNA transcription
GO:0009653 TAS anatomical structure morphogenesis
GO:0009887 TAS organ morphogenesis
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0030216 TAS keratinocyte differentiation
GO:0030728 ISS ovulation
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042060 TAS wound healing
GO:0042108 IDA positive regulation of cytokine biosynthetic process
GO:0042327 IDA positive regulation of phosphorylation
GO:0042700 ISS luteinizing hormone signaling pathway
GO:0043434 IEA response to peptide hormone
GO:0043616 IDA keratinocyte proliferation
GO:0045087 TAS innate immune response
GO:0045089 ISS positive regulation of innate immune response
GO:0045410 ISS positive regulation of interleukin-6 biosynthetic process
GO:0045740 ISS positive regulation of DNA replication
GO:0045741 ISS positive regulation of epidermal growth factor-activated receptor activity
GO:0045840 ISS positive regulation of mitosis
GO:0045860 IDA positive regulation of protein kinase activity
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048146 IDA positive regulation of fibroblast proliferation
GO:0048160 ISS primary follicle stage
GO:0048661 ISS positive regulation of smooth muscle cell proliferation
GO:0050680 TAS negative regulation of epithelial cell proliferation
GO:0051151 IDA negative regulation of smooth muscle cell differentiation
GO:0051781 IEA positive regulation of cell division

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000029377 Ereg epiregulin protein_coding Mus_musculus

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