C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: wingless-type MMTV integration site family, member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000125084 WNT1 9606 + 12:48978453-48981676 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000293549 WNT1-001 48978615-48981676 protein_coding
  ENST00000613114 WNT1-201 48978453-48981640 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainColonLungOvaryPlacentaTestisENST00000293549ENST00000613114
Transcript ID Adrenal Bladder Brain Colon Lung Ovary Placenta Testis
ENST00000293549 0.077±0.00 0.080±0.00 0.138±0.02 N/A 0.265±0.00 0.079±0.00 0.576±0.00 0.672±0.52
ENST00000613114 N/A N/A N/A 0.079±0.00 N/A N/A 1.056±0.00 0.252±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00033L CIL_00033L_0002 CGP 12:48965340-48981676
CIL_00000D CIL_00000D_0001 CGP 12:48978453-48999309

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000578 ISS embryonic axis specification
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0005102 IEA receptor binding
GO:0005109 IBA frizzled binding
GO:0005125 ISS cytokine activity
GO:0005515 IEA protein binding
GO:0005576 TAS:IEA extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IBA extracellular space
GO:0005737 IDA cytoplasm
GO:0005788 TAS endoplasmic reticulum lumen
GO:0005796 TAS Golgi lumen
GO:0005886 TAS plasma membrane
GO:0007267 ISS cell-cell signaling
GO:0007275 IEA multicellular organismal development
GO:0007520 IEA myoblast fusion
GO:0008284 IDA positive regulation of cell proliferation
GO:0009611 IEP response to wounding
GO:0009986 IEA cell surface
GO:0010592 IMP positive regulation of lamellipodium assembly
GO:0010812 IDA negative regulation of cell-substrate adhesion
GO:0014902 IEA myotube differentiation
GO:0016055 IDA:IEA Wnt signaling pathway
GO:0019904 IEA protein domain specific binding
GO:0021527 IEA spinal cord association neuron differentiation
GO:0021536 IEA diencephalon development
GO:0021551 ISS central nervous system morphogenesis
GO:0021588 ISS cerebellum formation
GO:0021797 IEA forebrain anterior/posterior pattern specification
GO:0022004 IEA midbrain-hindbrain boundary maturation during brain development
GO:0022037 IEA metencephalon development
GO:0022408 IMP negative regulation of cell-cell adhesion
GO:0030182 IBA neuron differentiation
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 IMP negative regulation of BMP signaling pathway
GO:0030579 IEA ubiquitin-dependent SMAD protein catabolic process
GO:0030901 ISS midbrain development
GO:0030917 IEA midbrain-hindbrain boundary development
GO:0031100 IEA organ regeneration
GO:0033077 IEA T cell differentiation in thymus
GO:0042472 IEA inner ear morphogenesis
GO:0042770 IDA signal transduction in response to DNA damage
GO:0043568 IDA positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044336 IMP canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045165 IBA cell fate commitment
GO:0045596 IEA negative regulation of cell differentiation
GO:0045599 ISS negative regulation of fat cell differentiation
GO:0045747 IDA positive regulation of Notch signaling pathway
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048018 IC receptor agonist activity
GO:0048146 IMP positive regulation of fibroblast proliferation
GO:0048663 IEA neuron fate commitment
GO:0048664 IEA neuron fate determination
GO:0051091 ISS positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060061 ISS Spemann organizer formation
GO:0060070 IMP canonical Wnt signaling pathway
GO:0060348 IMP bone development
GO:0061184 IDA positive regulation of dermatome development
GO:0070365 IEA hepatocyte differentiation
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0071425 IEA hematopoietic stem cell proliferation
GO:0090344 IDA negative regulation of cell aging
GO:2000059 IEA negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055554 wnt1 wingless-type MMTV integration site family, member 1 protein_coding Danio_rerio
ENSMUSG00000022997 Wnt1 wingless-type MMTV integration site family, member 1 protein_coding Mus_musculus

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