C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: endothelin 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000127129 EDN2 9606 - 1:41478775-41484673 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000372587 EDN2-001 41478775-41484671 protein_coding
  ENST00000460255 EDN2-004 41479454-41484085 processed_transcript
  ENST00000467046 EDN2-002 41479454-41484085 processed_transcript
  ENST00000467872 EDN2-003 41479454-41484085 processed_transcript
  ENST00000490783 EDN2-005 41479127-41484673 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000372587ENST00000460255ENST00000467872ENST00000490783
Transcript ID Adipose Bladder Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000372587 N/A 0.129±0.00 0.085±0.00 0.051±0.00 0.212±0.00 1.610±0.00 N/A 2.556±0.00 0.959±0.26 0.814±0.75 0.367±0.00
ENST00000460255 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.137±0.00
ENST00000467872 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.226±0.00
ENST00000490783 0.035±0.00 N/A 0.049±0.00 N/A N/A N/A 0.074±0.00 N/A N/A 0.389±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009C0 CIL_0009C0_0001 VISTA 1:40944924-41547265
CIL_000876 CIL_000876_0001 VISTA 1:40945428-41547337
CIL_0004JF CIL_0004JF_0002 CGP 1:41478775-42035925

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001516 IDA prostaglandin biosynthetic process
GO:0001659 IEA temperature homeostasis
GO:0002690 IDA positive regulation of leukocyte chemotaxis
GO:0003058 TAS hormonal regulation of the force of heart contraction
GO:0003099 TAS positive regulation of the force of heart contraction by chemical signal
GO:0003100 IDA regulation of systemic arterial blood pressure by endothelin
GO:0005179 IDA hormone activity
GO:0005576 TAS:IEA extracellular region
GO:0005615 IDA extracellular space
GO:0007166 IC cell surface receptor signaling pathway
GO:0007204 IDA positive regulation of cytosolic calcium ion concentration
GO:0008284 IDA positive regulation of cell proliferation
GO:0010460 IDA positive regulation of heart rate
GO:0014824 IDA artery smooth muscle contraction
GO:0014826 IDA vein smooth muscle contraction
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0019229 IEA regulation of vasoconstriction
GO:0019722 IDA calcium-mediated signaling
GO:0030593 IDA neutrophil chemotaxis
GO:0042116 IDA macrophage activation
GO:0042310 IDA vasoconstriction
GO:0045987 IEA positive regulation of smooth muscle contraction
GO:0048016 IDA inositol phosphate-mediated signaling
GO:0048246 IDA macrophage chemotaxis
GO:0048286 IEA lung alveolus development
GO:0060585 IMP positive regulation of prostaglandin-endoperoxide synthase activity
GO:0097009 IEA energy homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070578 edn2 endothelin 2 protein_coding Danio_rerio
ENSMUSG00000028635 Edn2 endothelin 2 protein_coding Mus_musculus

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