C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000127445 PIN1 9606 + 19:9835257-9849682 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000247970 PIN1-001 9835323-9849682 protein_coding
  ENST00000380889 PIN1-004 9835443-9849681 processed_transcript
  ENST00000585442 PIN1-011 9835347-9849274 processed_transcript
  ENST00000586025 PIN1-005 9835331-9849682 retained_intron
  ENST00000586352 PIN1-010 9835346-9849399 nonsense_mediated_decay
  ENST00000587625 PIN1-007 9835323-9848614 protein_coding
  ENST00000588695 PIN1-008 9835341-9849682 protein_coding
  ENST00000589058 PIN1-012 9835369-9849214 processed_transcript
  ENST00000590540 PIN1-009 9835340-9849682 processed_transcript
  ENST00000591777 PIN1-013 9838599-9849682 nonsense_mediated_decay
  ENST00000592184 PIN1-006 9835257-9836725 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000247970ENST00000586025ENST00000588695ENST00000589058ENST00000591777
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000247970 23.663±0.00 24.650±0.00 2.609±0.00 59.060±27.59 20.792±18.40 21.217±18.59 15.509±11.71 17.496±15.98 12.210±7.06 15.019±12.86 17.953±7.34 29.121±25.49 45.277±27.47 35.659±25.22
ENST00000586025 N/A 1.575±0.00 0.178±0.00 N/A 0.395±0.00 0.419±0.00 N/A 0.191±0.00 N/A 0.530±0.00 N/A 0.749±0.29 N/A 2.997±0.00
ENST00000588695 26.743±0.00 19.508±0.00 2.531±0.00 35.897±18.93 13.781±12.64 45.383±0.00 2.551±0.00 7.993±5.88 N/A 9.554±0.00 N/A 15.537±0.00 N/A 28.347±15.65
ENST00000589058 N/A N/A N/A N/A 3.207±0.00 5.583±0.00 N/A 2.701±0.00 N/A 2.278±0.00 5.141±0.00 7.743±3.08 20.627±0.00 20.757±0.00
ENST00000591777 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 11.280±0.00 N/A 17.779±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005J0 CIL_0005J0_0001 CGP 19:9827892-9849682
CIL_0005EY CIL_0005EY_0001 CGP 19:9835257-9936552

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000413 IEA protein peptidyl-prolyl isomerization
GO:0001934 IGI positive regulation of protein phosphorylation
GO:0003755 IDA peptidyl-prolyl cis-trans isomerase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0006457 IEA protein folding
GO:0007049 IEA cell cycle
GO:0007088 TAS regulation of mitosis
GO:0016853 IEA isomerase activity
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0030496 IDA midbody
GO:0030512 IDA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031434 IPI mitogen-activated protein kinase kinase binding
GO:0032321 IMP positive regulation of Rho GTPase activity
GO:0032465 IGI regulation of cytokinesis
GO:0032480 TAS negative regulation of type I interferon production
GO:0032794 IPI GTPase activating protein binding
GO:0045087 TAS innate immune response
GO:0050815 IDA phosphoserine binding
GO:0050816 IDA phosphothreonine binding
GO:0051443 IDA positive regulation of ubiquitin-protein transferase activity
GO:0060393 IDA regulation of pathway-restricted SMAD protein phosphorylation
GO:0070373 IDA negative regulation of ERK1 and ERK2 cascade
GO:2000146 IDA negative regulation of cell motility

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000089606 pin1 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 protein_coding Danio_rerio
ENSMUSG00000032171 Pin1 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 protein_coding Mus_musculus
ENSMUSG00000074997 Pin1rt1 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1, retrogene 1 protein_coding Mus_musculus

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