C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: toll-like receptor adaptor molecule 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000127666 TICAM1 9606 - 19:4815932-4831704 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000248244 TICAM1-001 4815932-4831704 protein_coding
  ENST00000621756 TICAM1-201 4816235-4817970 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000248244ENST00000621756
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000248244 9.041±0.00 6.736±0.00 1.119±0.00 2.724±2.52 2.462±2.03 2.882±2.33 1.454±1.24 3.695±2.60 1.870±1.58 12.118±11.48 7.312±7.07 8.391±5.93 6.992±1.28 2.039±1.16
ENST00000621756 N/A 2.326±0.00 N/A 1.156±0.74 1.305±0.72 1.112±0.00 N/A N/A 0.453±0.22 0.299±0.00 1.700±1.48 1.537±1.41 N/A 1.526±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00028H CIL_00028H_0001 CGP 19:4791681-4831704
CIL_00028M CIL_00028M_0001 CGP 19:4815932-4867768

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002281 IEA macrophage activation involved in immune response
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004871 IMP:IEA signal transducer activity
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0006954 IEA inflammatory response
GO:0007165 IEA signal transduction
GO:0007249 TAS I-kappaB kinase/NF-kappaB signaling
GO:0010008 TAS endosome membrane
GO:0019901 IPI protein kinase binding
GO:0030890 IEA positive regulation of B cell proliferation
GO:0031398 IEA positive regulation of protein ubiquitination
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0032092 IEA positive regulation of protein binding
GO:0032481 IEA positive regulation of type I interferon production
GO:0032496 IEA response to lipopolysaccharide
GO:0032755 IEA positive regulation of interleukin-6 production
GO:0032760 IEA positive regulation of tumor necrosis factor production
GO:0032816 IEA positive regulation of natural killer cell activation
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 IMP response to exogenous dsRNA
GO:0043496 IEA regulation of protein homodimerization activity
GO:0045080 IEA positive regulation of chemokine biosynthetic process
GO:0045087 TAS:IEA innate immune response
GO:0045359 IEA positive regulation of interferon-beta biosynthetic process
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0050871 IEA positive regulation of B cell activation
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051607 IEA defense response to virus
GO:0097190 IEA apoptotic signaling pathway
GO:0097342 IDA ripoptosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042714 ticam1 toll-like receptor adaptor molecule 1 protein_coding Danio_rerio
ENSDARG00000086136 ticam1 toll-like receptor adaptor molecule 1 protein_coding Danio_rerio
ENSMUSG00000047123 Ticam1 toll-like receptor adaptor molecule 1 protein_coding Mus_musculus

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