C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000131042 LILRB2 9606 - 19:54238904-54281184 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000314446 LILRB2-004 54274352-54281184 protein_coding
  ENST00000391746 LILRB2-005 54274466-54280498 protein_coding
  ENST00000391748 LILRB2-001 54273821-54280883 protein_coding
  ENST00000391749 LILRB2-003 54274466-54281184 protein_coding
  ENST00000434421 LILRB2-201 54273822-54281178 protein_coding
  ENST00000455108 LILRB2-007 54274466-54278544 nonsense_mediated_decay
  ENST00000471216 LILRB2-008 54279850-54280461 processed_transcript
  ENST00000493242 LILRB2-002 54274466-54281097 retained_intron
  ENST00000612280 LILRB2-202 54238904-54280534 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000314446ENST00000391746ENST00000391748ENST00000391749ENST00000434421ENST00000455108ENST00000493242
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000314446 N/A N/A N/A N/A N/A N/A N/A 0.705±0.00 N/A N/A N/A 2.570±0.00 N/A
ENST00000391746 3.615±0.00 N/A 0.359±0.00 N/A N/A 0.760±0.00 N/A N/A N/A 18.043±0.00 N/A N/A N/A
ENST00000391748 2.979±0.00 4.075±0.00 N/A N/A 1.520±0.00 N/A 0.920±0.00 0.569±0.30 1.093±0.00 N/A 0.645±0.36 1.751±0.89 0.205±0.07
ENST00000391749 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.896±0.00 N/A N/A N/A
ENST00000434421 N/A N/A N/A 0.059±0.00 0.174±0.00 N/A 0.026±0.00 N/A N/A N/A N/A N/A N/A
ENST00000455108 N/A N/A 0.131±0.00 N/A N/A N/A 0.051±0.00 N/A N/A N/A N/A N/A N/A
ENST00000493242 N/A N/A N/A N/A 0.377±0.00 N/A N/A N/A N/A N/A 1.355±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005M6 CIL_0005M6_0001 CGP 19:54189938-54249003

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002578 IDA negative regulation of antigen processing and presentation
GO:0002666 IMP positive regulation of T cell tolerance induction
GO:0002767 IMP immune response-inhibiting cell surface receptor signaling pathway
GO:0002774 IDA Fc receptor mediated inhibitory signaling pathway
GO:0004872 TAS receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005615 IDA extracellular space
GO:0005737 IDA cytoplasm
GO:0005886 TAS plasma membrane
GO:0005887 IC integral component of plasma membrane
GO:0006955 TAS immune response
GO:0006968 TAS cellular defense response
GO:0007165 IMP signal transduction
GO:0007166 TAS cell surface receptor signaling pathway
GO:0007267 TAS cell-cell signaling
GO:0008157 IPI protein phosphatase 1 binding
GO:0009986 IDA cell surface
GO:0016020 TAS membrane
GO:0023029 IPI MHC class Ib protein binding
GO:0032396 IMP inhibitory MHC class I receptor activity
GO:0032755 NAS positive regulation of interleukin-6 production
GO:0034113 IDA heterotypic cell-cell adhesion
GO:0042102 IDA positive regulation of T cell proliferation
GO:0042130 IMP negative regulation of T cell proliferation
GO:0042288 IDA MHC class I protein binding
GO:0045591 IMP positive regulation of regulatory T cell differentiation
GO:0050776 TAS regulation of immune response
GO:0050839 IPI cell adhesion molecule binding
GO:0051926 IDA negative regulation of calcium ion transport
GO:0071222 IMP cellular response to lipopolysaccharide
GO:2001198 IC regulation of dendritic cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000030427 Lilra6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 protein_coding Mus_musculus
ENSMUSG00000058818 Pirb paired Ig-like receptor B protein_coding Mus_musculus
ENSMUSG00000070873 Lilra5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 protein_coding Mus_musculus
ENSMUSG00000074417 Gm14548 predicted gene 14548 protein_coding Mus_musculus
ENSMUSG00000074419 Gm15448 predicted gene 15448 protein_coding Mus_musculus
ENSMUSG00000089942 Pira2 paired-Ig-like receptor A2 protein_coding Mus_musculus

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