C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pyruvate dehydrogenase (lipoamide) alpha 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000131828 PDHA1 9606 + X:19343893-19361705 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000355808 PDHA1-008 19343950-19354570 protein_coding
  ENST00000379804 PDHA1-002 19355582-19359844 protein_coding
  ENST00000379805 PDHA1-001 19343968-19353327 protein_coding
  ENST00000379806 PDHA1-201 19343893-19361705 protein_coding
  ENST00000417819 PDHA1-010 19343930-19350098 protein_coding
  ENST00000422285 PDHA1-004 19343933-19361685 protein_coding
  ENST00000423505 PDHA1-009 19343922-19353164 protein_coding
  ENST00000478795 PDHA1-006 19357382-19359832 processed_transcript
  ENST00000479146 PDHA1-003 19352829-19355445 processed_transcript
  ENST00000481733 PDHA1-005 19355318-19359025 processed_transcript
  ENST00000492364 PDHA1-007 19343936-19351498 processed_transcript
  ENST00000540249 PDHA1-202 19343893-19361705 protein_coding
  ENST00000545074 PDHA1-203 19343893-19361705 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000355808ENST00000379804ENST00000379805ENST00000379806ENST00000422285ENST00000481733
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000355808 15.861±0.00 N/A N/A N/A N/A N/A 125.342±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000379804 21.445±0.00 N/A 20.657±0.00 36.457±9.72 25.252±15.15 23.167±3.37 69.287±0.00 18.993±0.00 20.401±3.71 13.757±0.76 40.998±10.03 26.134±10.75 15.831±0.31 14.453±3.23
ENST00000379805 N/A N/A 10.558±0.00 N/A N/A 11.990±0.00 N/A N/A 11.173±0.00 7.931±0.00 16.334±0.00 20.434±0.00 N/A N/A
ENST00000379806 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.539±0.00 N/A
ENST00000422285 3.899±0.00 4.806±0.00 3.808±0.00 6.299±0.59 10.661±0.00 3.273±1.37 16.567±5.96 8.337±3.24 3.595±0.74 2.295±0.52 4.833±0.00 4.338±2.32 3.841±0.60 4.506±0.00
ENST00000481733 22.596±0.00 N/A N/A 33.833±0.00 42.976±0.00 22.124±0.00 N/A 24.110±0.00 23.000±0.00 17.292±1.23 N/A N/A N/A 25.389±0.93

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004738 IDA pyruvate dehydrogenase activity
GO:0004739 IEA pyruvate dehydrogenase (acetyl-transferring) activity
GO:0005634 IDA nucleus
GO:0005739 IDA mitochondrion
GO:0005759 TAS mitochondrial matrix
GO:0006006 IEA glucose metabolic process
GO:0006086 IDA acetyl-CoA biosynthetic process from pyruvate
GO:0006090 TAS pyruvate metabolic process
GO:0006096 IEA glycolytic process
GO:0006099 IDA tricarboxylic acid cycle
GO:0008152 IEA metabolic process
GO:0010510 TAS regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0016624 IEA oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0044237 TAS cellular metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045254 IDA pyruvate dehydrogenase complex
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010555 pdha1b pyruvate dehydrogenase (lipoamide) alpha 1b protein_coding Danio_rerio
ENSDARG00000012387 pdha1a pyruvate dehydrogenase (lipoamide) alpha 1a protein_coding Danio_rerio
ENSMUSG00000031299 Pdha1 pyruvate dehydrogenase E1 alpha 1 protein_coding Mus_musculus

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