C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serine peptidase inhibitor, Kazal type 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000133710 SPINK5 9606 + 5:148025683-148137289 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000256084 SPINK5-001 148064003-148137289 protein_coding
  ENST00000359874 SPINK5-003 148063972-148137289 protein_coding
  ENST00000398454 SPINK5-002 148063972-148124940 protein_coding
  ENST00000476608 SPINK5-006 148090928-148101428 processed_transcript
  ENST00000476697 SPINK5-012 148063980-148095900 nonsense_mediated_decay
  ENST00000481286 SPINK5-005 148090653-148098003 processed_transcript
  ENST00000507988 SPINK5-009 148063984-148118989 retained_intron
  ENST00000508733 SPINK5-008 148063980-148123960 protein_coding
  ENST00000521206 SPINK5-011 148025683-148072201 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLungOvaryPlacentaTestisENST00000256084ENST00000359874ENST00000398454ENST00000476608ENST00000476697ENST00000507988ENST00000508733
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Lung Ovary Placenta Testis
ENST00000256084 0.536±0.00 0.054±0.00 N/A 0.014±0.00 0.053±0.04 0.114±0.00 0.123±0.00 0.117±0.00 0.347±0.00 2.427±2.59 0.208±0.01 0.448±0.00
ENST00000359874 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.410±4.36 0.101±0.05 0.150±0.00
ENST00000398454 N/A N/A N/A N/A 0.036±0.00 N/A N/A N/A N/A N/A N/A 0.231±0.00
ENST00000476608 N/A N/A N/A N/A N/A N/A N/A 0.085±0.00 N/A N/A N/A N/A
ENST00000476697 N/A N/A 0.021±0.00 0.174±0.12 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000507988 N/A N/A 0.014±0.00 N/A 0.178±0.00 N/A N/A 0.108±0.00 N/A 1.932±0.00 N/A N/A
ENST00000508733 N/A N/A N/A 0.007±0.00 N/A N/A N/A N/A N/A 4.399±3.67 0.242±0.00 0.324±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000257 CIL_000257_0001 CGP 5:147880726-148137289
CIL_0001KU CIL_0001KU_0001 CGP 5:148025683-148175398

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004867 IDA serine-type endopeptidase inhibitor activity
GO:0005515 IEA protein binding
GO:0005576 NAS extracellular region
GO:0005737 IDA cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005789 IDA endoplasmic reticulum membrane
GO:0005829 IDA cytosol
GO:0005938 IDA cell cortex
GO:0009913 IDA epidermal cell differentiation
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0016525 TAS negative regulation of angiogenesis
GO:0030155 IEA regulation of cell adhesion
GO:0030198 TAS extracellular matrix organization
GO:0030414 IEA peptidase inhibitor activity
GO:0030855 TAS epithelial cell differentiation
GO:0035315 TAS hair cell differentiation
GO:0042640 TAS anagen
GO:0045580 TAS regulation of T cell differentiation
GO:0045861 IEA negative regulation of proteolysis
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050777 TAS negative regulation of immune response
GO:0070062 IDA extracellular vesicular exosome
GO:0097209 IDA epidermal lamellar body
GO:1902572 IEA negative regulation of serine-type peptidase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000055561 Spink5 serine peptidase inhibitor, Kazal type 5 protein_coding Mus_musculus

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