C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: complement component 5a receptor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134830 C5AR2 9606 + 19:47332147-47347327 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000595464 C5AR2-001 47332147-47347327 protein_coding
  ENST00000600626 C5AR2-002 47337114-47342015 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverMuscleOvaryPlacentaTestisENST00000595464ENST00000600626
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Muscle Ovary Placenta Testis
ENST00000595464 0.464±0.00 0.763±0.00 N/A 0.309±0.00 0.273±0.21 0.142±0.14 0.100±0.08 0.546±0.00 0.206±0.16 0.023±0.02 0.326±0.12 0.265±0.10 0.467±0.00
ENST00000600626 N/A N/A 0.382±0.00 0.386±0.00 N/A N/A N/A N/A N/A N/A 0.696±0.00 1.452±0.37 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008G1 CIL_0008G1_0001 VISTA 19:46806794-47408636

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004930 IEA G-protein coupled receptor activity
GO:0004944 IEA C5a anaphylatoxin receptor activity
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0006935 IEA chemotaxis
GO:0006954 IEA inflammatory response
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0009925 IDA basal plasma membrane
GO:0016021 IEA integral component of membrane
GO:0032720 IMP negative regulation of tumor necrosis factor production
GO:0045177 IDA apical part of cell
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0090024 IMP negative regulation of neutrophil chemotaxis
GO:1900165 IMP negative regulation of interleukin-6 secretion
GO:2000482 IMP regulation of interleukin-8 secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040319 C5AR1 C5a anaphylatoxin chemotactic receptor 1 protein_coding Danio_rerio
ENSMUSG00000074361 C5ar2 complement component 5a receptor 2 protein_coding Mus_musculus

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