C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: complement component 5a receptor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000074361 C5ar2 10090 - 7:16234585-16244154 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000098792 C5ar2-201 16234585-16242331 protein_coding
  ENSMUST00000171425 C5ar2-202 16234585-16244154 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000098792ENSMUST00000171425
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000098792 0.160±0.06 0.570±0.14 0.098±0.05 0.749±0.58 0.394±0.14 0.311±0.11 0.185±0.04 0.237±0.07 1.237±0.57 0.088±0.07 0.545±0.23 N/A 0.035±0.02
ENSMUST00000171425 0.223±0.00 0.360±0.09 N/A 0.650±0.39 0.394±0.00 N/A 0.191±0.00 0.180±0.06 0.323±0.06 0.013±0.00 0.666±0.08 0.434±0.00 0.045±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008G1 CIL_0008G1_0002 VISTA 7:16104746-16706411

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004944 IEA C5a anaphylatoxin receptor activity
GO:0005515 IEA protein binding
GO:0006935 IEA chemotaxis
GO:0006954 IEA inflammatory response
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0009925 ISS basal plasma membrane
GO:0016021 IEA integral component of membrane
GO:0032720 ISS negative regulation of tumor necrosis factor production
GO:0045177 ISS apical part of cell
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0090024 ISS negative regulation of neutrophil chemotaxis
GO:1900165 ISS negative regulation of interleukin-6 secretion
GO:2000482 ISS regulation of interleukin-8 secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040319 C5AR1 C5a anaphylatoxin chemotactic receptor 1 protein_coding Danio_rerio
ENSG00000134830 C5AR2 complement component 5a receptor 2 protein_coding Homo_sapiens

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