C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: egl-9 family hypoxia-inducible factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000135766 EGLN1 9606 - 1:231363751-231425044 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000366641 EGLN1-001 231363751-231425044 protein_coding
  ENST00000476717 EGLN1-002 231366140-231420343 processed_transcript

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000366641ENST00000476717
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000366641 1.875±0.00 0.748±0.00 5.040±0.00 5.011±0.00 2.919±0.00 3.263±1.95 4.973±0.57 2.970±1.56 3.929±2.99 2.161±1.53 13.319±3.82 1.474±0.73 1.661±0.44 1.546±0.00
ENST00000476717 N/A N/A N/A 9.615±0.00 7.695±0.00 5.581±0.00 8.500±0.00 9.606±0.00 13.885±0.00 4.272±0.00 13.156±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006AZ CIL_0006AZ_0001 CGP 1:231337104-231425044
CIL_0006AY CIL_0006AY_0001 CGP 1:231363751-231819244

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IDA response to hypoxia
GO:0005506 IEA iron ion binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0016491 IEA oxidoreductase activity
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0018401 IDA peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0019899 ISS enzyme binding
GO:0030821 ISS negative regulation of cAMP catabolic process
GO:0031418 IEA L-ascorbic acid binding
GO:0031543 TAS peptidyl-proline dioxygenase activity
GO:0031545 IDA peptidyl-proline 4-dioxygenase activity
GO:0032364 IDA oxygen homeostasis
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045765 ISS regulation of angiogenesis
GO:0051344 ISS negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0055008 IEA cardiac muscle tissue morphogenesis
GO:0055114 IEA oxidation-reduction process
GO:0060347 IEA heart trabecula formation
GO:0060412 IEA ventricular septum morphogenesis
GO:0060711 IEA labyrinthine layer development
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 TAS cellular response to hypoxia
GO:0071731 IDA response to nitric oxide

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004632 egln1 egl nine homolog 1 (C. elegans) protein_coding Danio_rerio
ENSDARG00000038996 EGLN1 (2 of 2) egl-9 family hypoxia-inducible factor 1 protein_coding Danio_rerio
ENSMUSG00000031987 Egln1 egl-9 family hypoxia-inducible factor 1 protein_coding Mus_musculus

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