C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mediator of DNA-damage checkpoint 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000137337 MDC1 9606 - 6:30699807-30717889 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000376406 MDC1-001 30699807-30717889 protein_coding
  ENST00000416571 MDC1-003 30713833-30717175 protein_coding
  ENST00000417033 MDC1-006 30705448-30711914 protein_coding
  ENST00000422266 MDC1-004 30713980-30717121 protein_coding
  ENST00000425072 MDC1-002 30713940-30717447 protein_coding
  ENST00000489540 MDC1-008 30700315-30704081 retained_intron
  ENST00000492462 MDC1-007 30705582-30707685 retained_intron
  ENST00000494654 MDC1-005 30711472-30711931 processed_transcript
  ENST00000613547 MDC1-201 30713208-30717075 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000376406ENST00000417033ENST00000489540
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000376406 1.705±0.00 1.409±0.00 0.732±0.00 1.682±0.00 0.576±0.05 0.776±0.00 0.082±0.00 1.108±0.24 0.732±0.13 0.706±0.00 5.296±2.63 2.887±0.94 9.454±6.94
ENST00000417033 N/A N/A N/A N/A N/A N/A N/A 2.658±0.00 N/A N/A N/A N/A N/A
ENST00000489540 N/A 5.236±0.00 N/A N/A N/A 1.523±0.00 N/A N/A 2.321±0.00 3.682±0.00 14.104±5.22 10.000±0.00 30.611±21.76

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00090O CIL_00090O_0001 VISTA 6:30539989-31144784

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000724 TAS double-strand break repair via homologous recombination
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005694 ISS chromosome
GO:0005925 IDA focal adhesion
GO:0006281 TAS DNA repair
GO:0006302 TAS double-strand break repair
GO:0008022 IPI protein C-terminus binding
GO:0031573 TAS intra-S DNA damage checkpoint
GO:0070975 IPI FHA domain binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000086764 MDC1 mediator of DNA-damage checkpoint 1 protein_coding Danio_rerio
ENSMUSG00000061607 Mdc1 mediator of DNA damage checkpoint 1 protein_coding Mus_musculus

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