C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transmembrane BAX inhibitor motif containing 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000139644 TMBIM6 9606 + 12:49707725-49764934 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000267115 TMBIM6-002 49741557-49764933 protein_coding
  ENST00000395006 TMBIM6-007 49752456-49764742 protein_coding
  ENST00000423828 TMBIM6-201 49741809-49764934 protein_coding
  ENST00000546796 TMBIM6-027 49738993-49758483 protein_coding
  ENST00000546885 TMBIM6-014 49741571-49742488 retained_intron
  ENST00000546914 TMBIM6-029 49741557-49755756 protein_coding
  ENST00000547013 TMBIM6-025 49758207-49761783 retained_intron
  ENST00000547187 TMBIM6-011 49741549-49755756 protein_coding
  ENST00000547798 TMBIM6-006 49752964-49764723 protein_coding
  ENST00000547832 TMBIM6-012 49741547-49758462 protein_coding
  ENST00000548201 TMBIM6-017 49741608-49758438 protein_coding
  ENST00000548589 TMBIM6-010 49707733-49715777 processed_transcript
  ENST00000548713 TMBIM6-013 49741608-49752524 protein_coding
  ENST00000548809 TMBIM6-008 49707725-49752526 protein_coding
  ENST00000548894 TMBIM6-019 49741557-49752542 protein_coding
  ENST00000549130 TMBIM6-028 49743417-49755736 protein_coding
  ENST00000549385 TMBIM6-003 49741574-49764726 protein_coding
  ENST00000549445 TMBIM6-016 49741568-49755756 protein_coding
  ENST00000549471 TMBIM6-024 49759136-49763094 retained_intron
  ENST00000549966 TMBIM6-026 49741544-49758265 protein_coding
  ENST00000550040 TMBIM6-023 49758804-49762137 retained_intron
  ENST00000550445 TMBIM6-018 49741822-49758686 protein_coding
  ENST00000550951 TMBIM6-015 49741571-49753049 protein_coding
  ENST00000551154 TMBIM6-009 49707733-49753039 protein_coding
  ENST00000552370 TMBIM6-020 49750620-49762948 protein_coding
  ENST00000552635 TMBIM6-021 49741557-49758707 nonsense_mediated_decay
  ENST00000552699 TMBIM6-001 49741557-49764737 protein_coding
  ENST00000553022 TMBIM6-022 49753038-49758708 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000267115ENST00000395006ENST00000547798ENST00000549966ENST00000552635ENST00000552699
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000267115 32.496±0.00 30.503±0.00 47.861±0.00 25.781±0.19 46.861±2.17 41.456±3.13 18.436±14.63 143.515±9.66 85.458±68.17 81.129±37.01 23.284±15.61 63.518±30.05 58.276±2.14 34.740±0.00
ENST00000395006 120.818±0.00 66.872±0.00 N/A 43.843±22.29 79.789±0.00 35.110±15.22 15.511±5.68 47.642±0.00 25.726±0.00 N/A N/A 59.855±27.91 88.986±5.53 53.991±0.00
ENST00000547798 44.341±0.00 67.033±0.00 11.173±0.00 77.436±0.00 84.743±0.00 74.562±0.00 34.345±0.00 98.022±12.00 156.118±0.00 86.436±64.51 35.696±19.45 104.760±39.32 70.203±25.08 40.390±11.81
ENST00000549966 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 92.971±0.00
ENST00000552635 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 208.782±0.00 263.156±0.00 116.172±0.00
ENST00000552699 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 26.786±5.77

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00009O CIL_00009O_0001 CGP 12:49636499-49764934
CIL_00003M CIL_00003M_0001 CGP 12:49707725-49828750

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005634 TAS nucleus
GO:0005783 IEA endoplasmic reticulum
GO:0005887 TAS integral component of plasma membrane
GO:0006915 IEA apoptotic process
GO:0006986 IEA response to unfolded protein
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0032469 IEA endoplasmic reticulum calcium ion homeostasis
GO:0043066 IEA negative regulation of apoptotic process
GO:0070059 IEA intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1902236 IEA negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000077934 tegt testis enhanced gene transcript (BAX inhibitor 1) protein_coding Danio_rerio
ENSMUSG00000023010 Tmbim6 transmembrane BAX inhibitor motif containing 6 protein_coding Mus_musculus

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