C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: retinoblastoma 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000139687 RB1 9606 + 13:48303751-48481986 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000267163 RB1-002 48303775-48481986 protein_coding
  ENST00000467505 RB1-003 48303775-48362908 nonsense_mediated_decay
  ENST00000480491 RB1-004 48444828-48456307 processed_transcript
  ENST00000484879 RB1-001 48476447-48480647 processed_transcript
  ENST00000525036 RB1-006 48303751-48360737 retained_intron
  ENST00000531171 RB1-005 48476400-48480339 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000267163ENST00000484879ENST00000531171
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000267163 7.523±0.00 6.112±0.00 1.803±0.00 4.436±0.49 6.302±0.12 5.464±0.29 3.671±0.96 4.336±2.22 2.807±1.48 3.088±0.50 4.496±1.80 4.576±1.85 3.123±0.53 4.840±1.86
ENST00000484879 N/A N/A N/A N/A 6.930±0.00 N/A N/A N/A N/A N/A N/A 3.120±0.00 6.974±0.00 1.956±0.00
ENST00000531171 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.656±0.00 N/A 3.241±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00078H CIL_00078H_0002 CGP 13:48303751-48481986

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000075 TAS cell cycle checkpoint
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000083 TAS regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000278 TAS mitotic cell cycle
GO:0000785 TAS chromatin
GO:0001047 IDA core promoter binding
GO:0001102 IEA RNA polymerase II activating transcription factor binding
GO:0003674 ND molecular_function
GO:0003677 TAS DNA binding
GO:0003700 TAS sequence-specific DNA binding transcription factor activity
GO:0003713 NAS transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005575 ND cellular_component
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005819 IEA spindle
GO:0006338 TAS chromatin remodeling
GO:0006351 IEA transcription, DNA-templated
GO:0006469 IPI negative regulation of protein kinase activity
GO:0007050 TAS cell cycle arrest
GO:0007070 TAS negative regulation of transcription from RNA polymerase II promoter during mitosis
GO:0007093 TAS mitotic cell cycle checkpoint
GO:0007265 IEP Ras protein signal transduction
GO:0007346 IMP regulation of mitotic cell cycle
GO:0008134 IPI transcription factor binding
GO:0008150 ND biological_process
GO:0008285 IEA negative regulation of cell proliferation
GO:0016032 IEA viral process
GO:0016514 TAS SWI/SNF complex
GO:0016605 IDA PML body
GO:0019899 IEA enzyme binding
GO:0019900 IDA kinase binding
GO:0030182 IEA neuron differentiation
GO:0030521 NAS androgen receptor signaling pathway
GO:0031134 IMP sister chromatid biorientation
GO:0031175 IEA neuron projection development
GO:0031625 IPI ubiquitin protein ligase binding
GO:0034088 IMP maintenance of mitotic sister chromatid cohesion
GO:0034349 IEA glial cell apoptotic process
GO:0035189 TAS Rb-E2F complex
GO:0035914 IEA skeletal muscle cell differentiation
GO:0042551 IEA neuron maturation
GO:0042802 IPI identical protein binding
GO:0043353 IEA enucleate erythrocyte differentiation
GO:0043433 TAS negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043550 IDA regulation of lipid kinase activity
GO:0045445 IMP myoblast differentiation
GO:0045651 IEA positive regulation of macrophage differentiation
GO:0045786 IEA negative regulation of cell cycle
GO:0045842 IMP positive regulation of mitotic metaphase/anaphase transition
GO:0045879 IEA negative regulation of smoothened signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 NAS positive regulation of transcription, DNA-templated
GO:0045930 IEA negative regulation of mitotic cell cycle
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048565 IEA digestive tract development
GO:0048667 IEA cell morphogenesis involved in neuron differentiation
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0050681 NAS androgen receptor binding
GO:0051146 IEA striated muscle cell differentiation
GO:0051219 IPI phosphoprotein binding
GO:0051301 IEA cell division
GO:0051402 IEA neuron apoptotic process
GO:0051726 IEA regulation of cell cycle
GO:0071459 IMP protein localization to chromosome, centromeric region
GO:0071922 IMP regulation of cohesin localization to chromatin
GO:0071930 IEA negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0090230 TAS regulation of centromere complex assembly
GO:0097284 IEA hepatocyte apoptotic process
GO:2000134 TAS negative regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006782 rb1 retinoblastoma 1 protein_coding Danio_rerio
ENSMUSG00000022105 Rb1 retinoblastoma 1 protein_coding Mus_musculus

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