C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NLR family, pyrin domain containing 12
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000142405 NLRP12 9606 - 19:53793603-53824394 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000324134 NLRP12-001 53793603-53824343 protein_coding
  ENST00000345770 NLRP12-004 53793743-53824394 protein_coding
  ENST00000391772 NLRP12-007 53793743-53824394 protein_coding
  ENST00000391773 NLRP12-002 53793743-53824394 protein_coding
  ENST00000391775 NLRP12-003 53793742-53824317 protein_coding
  ENST00000492915 NLRP12-005 53793743-53808705 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000324134ENST00000345770ENST00000391772ENST00000391775ENST00000492915
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000324134 N/A 0.167±0.00 0.025±0.00 0.105±0.00 0.022±0.00 0.018±0.00 0.330±0.00 0.093±0.00 0.498±0.00 0.010±0.00 0.077±0.01 0.335±0.20 0.187±0.04
ENST00000345770 0.193±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000391772 N/A N/A N/A N/A 0.169±0.00 0.075±0.00 N/A 0.113±0.00 0.088±0.00 N/A 0.049±0.00 N/A N/A
ENST00000391775 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.422±0.00 N/A
ENST00000492915 0.115±0.00 0.266±0.00 0.153±0.00 0.114±0.01 0.050±0.00 0.060±0.00 0.202±0.00 0.045±0.00 N/A 0.025±0.00 0.046±0.02 N/A 0.135±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004ML CIL_0004ML_0001 CGP 19:53793603-53876437

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0006919 NAS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 NAS signal transduction
GO:0008588 IDA release of cytoplasmic sequestered NF-kappaB
GO:0008656 NAS cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0009968 IDA negative regulation of signal transduction
GO:0031953 IDA negative regulation of protein autophosphorylation
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0036336 IEA dendritic cell migration
GO:0043122 IDA regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 IDA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043281 IDA regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045345 IDA positive regulation of MHC class I biosynthetic process
GO:0045381 NAS regulation of interleukin-18 biosynthetic process
GO:0045409 IDA negative regulation of interleukin-6 biosynthetic process
GO:0045751 IDA negative regulation of Toll signaling pathway
GO:0050710 IDA negative regulation of cytokine secretion
GO:0050711 IDA negative regulation of interleukin-1 secretion
GO:0050718 NAS positive regulation of interleukin-1 beta secretion
GO:0050728 IMP negative regulation of inflammatory response
GO:0050729 NAS positive regulation of inflammatory response
GO:0070373 IEA negative regulation of ERK1 and ERK2 cascade
GO:0071345 IEA cellular response to cytokine stimulus
GO:1901223 IEA negative regulation of NIK/NF-kappaB signaling

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000078817 Nlrp12 NLR family, pyrin domain containing 12 protein_coding Mus_musculus

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