C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ABL proto-oncogene 2, non-receptor tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000143322 ABL2 9606 - 1:179099327-179229684 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000344730 ABL2-002 179104048-179143089 protein_coding
  ENST00000367623 ABL2-008 179107718-179229397 protein_coding
  ENST00000392043 ABL2-007 179110581-179229684 protein_coding
  ENST00000502732 ABL2-001 179099327-179229601 protein_coding
  ENST00000504324 ABL2-003 179116852-179143076 retained_intron
  ENST00000504405 ABL2-006 179107718-179143044 protein_coding
  ENST00000507173 ABL2-009 179107718-179229397 protein_coding
  ENST00000508127 ABL2-011 179131212-179143074 retained_intron
  ENST00000509520 ABL2-004 179116823-179143069 retained_intron
  ENST00000511413 ABL2-010 179107718-179229397 protein_coding
  ENST00000512653 ABL2-005 179107599-179143056 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000344730ENST00000502732
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000344730 N/A N/A 0.622±0.00 2.173±0.00 0.424±0.00 0.140±0.00 N/A 1.018±0.00 N/A 0.656±0.00 1.278±0.00 N/A N/A
ENST00000502732 0.773±0.00 0.746±0.00 0.900±0.59 0.592±0.00 0.904±0.74 0.235±0.05 0.154±0.00 0.762±0.00 2.368±0.00 N/A 0.849±0.37 0.496±0.00 1.260±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0001891 IEA phagocytic cup
GO:0003785 TAS actin monomer binding
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0006464 TAS cellular protein modification process
GO:0006468 IEA protein phosphorylation
GO:0006909 IEA phagocytosis
GO:0006930 IEA substrate-dependent cell migration, cell extension
GO:0007015 IEA actin filament organization
GO:0007155 IEA cell adhesion
GO:0007165 TAS signal transduction
GO:0007173 IEA epidermal growth factor receptor signaling pathway
GO:0007204 IMP positive regulation of cytosolic calcium ion concentration
GO:0007411 TAS axon guidance
GO:0007612 IEA learning
GO:0008542 IEA visual learning
GO:0010506 TAS regulation of autophagy
GO:0010863 IMP positive regulation of phospholipase C activity
GO:0010976 IMP positive regulation of neuron projection development
GO:0015629 TAS actin cytoskeleton
GO:0016322 IEA neuron remodeling
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0021587 IEA cerebellum morphogenesis
GO:0022408 IEA negative regulation of cell-cell adhesion
GO:0030027 IEA lamellipodium
GO:0030100 TAS regulation of endocytosis
GO:0030145 IDA manganese ion binding
GO:0030155 TAS regulation of cell adhesion
GO:0032092 IEA positive regulation of protein binding
GO:0034613 IEA cellular protein localization
GO:0035024 IEA negative regulation of Rho protein signal transduction
GO:0035640 IEA exploration behavior
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043197 IEA dendritic spine
GO:0046632 IEA alpha-beta T cell differentiation
GO:0048008 IEA platelet-derived growth factor receptor signaling pathway
GO:0048813 IEA dendrite morphogenesis
GO:0050885 IEA neuromuscular process controlling balance
GO:0051015 TAS actin filament binding
GO:0051017 IEA actin filament bundle assembly
GO:0051353 IDA positive regulation of oxidoreductase activity
GO:0060020 IEA Bergmann glial cell differentiation
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071300 IMP cellular response to retinoic acid
GO:0097062 IEA dendritic spine maintenance
GO:1900042 IEA positive regulation of interleukin-2 secretion
GO:1902715 IEA positive regulation of interferon-gamma secretion
GO:1903053 IEA regulation of extracellular matrix organization
GO:2000096 IEA positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000145 TAS regulation of cell motility
GO:2000249 TAS regulation of actin cytoskeleton reorganization
GO:2000352 IEA negative regulation of endothelial cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013841 abl2 v-abl Abelson murine leukemia viral oncogene homolog 2 protein_coding Danio_rerio
ENSMUSG00000026596 Abl2 v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) protein_coding Mus_musculus

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