C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Mitogen-activated protein kinase kinase kinase MLK4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000143674 MLK4 9606 + 1:233327768-233385148 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000366622 MLK4-003 233375783-233385147 protein_coding
  ENST00000366623 MLK4-002 233327768-233374134 protein_coding
  ENST00000366624 MLK4-001 233327768-233385148 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000366622ENST00000366623ENST00000366624
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000366622 N/A 0.222±0.00 N/A N/A 0.215±0.12 0.292±0.00 N/A 1.795±0.00 0.293±0.00 N/A 0.635±0.31 0.043±0.00 1.245±0.00
ENST00000366623 N/A 0.068±0.00 0.687±0.00 N/A N/A N/A 0.021±0.00 0.129±0.00 0.126±0.00 0.520±0.00 0.521±0.00 N/A 0.695±0.00
ENST00000366624 0.149±0.00 N/A 1.840±0.00 0.682±0.09 0.695±0.28 0.958±0.64 0.054±0.03 2.112±1.72 0.187±0.06 0.732±0.26 0.825±0.82 0.117±0.07 1.620±0.55

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006KA CIL_0006KA_0001 CGP 1:232983435-233385148
CIL_0006KB CIL_0006KB_0001 CGP 1:233327768-233672512

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 IEA activation of MAPKK activity
GO:0004672 IEA protein kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005575 ND cellular_component
GO:0006468 IEA protein phosphorylation
GO:0007257 ISS activation of JUN kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0042803 ISS protein homodimerization activity
GO:0046777 ISS protein autophosphorylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079473 si:ch211-120p12.3 si:ch211-120p12.3 protein_coding Danio_rerio
ENSMUSG00000031853 BC021891 cDNA sequence BC021891 protein_coding Mus_musculus

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