C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: poly (ADP-ribose) polymerase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000143799 PARP1 9606 - 1:226360691-226408075 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000366790 PARP1-003 226401983-226407982 protein_coding
  ENST00000366792 PARP1-005 226392258-226408075 protein_coding
  ENST00000366794 PARP1-001 226360691-226408073 protein_coding
  ENST00000463968 PARP1-007 226361319-226364372 processed_transcript
  ENST00000468608 PARP1-008 226361708-226363160 processed_transcript
  ENST00000469663 PARP1-004 226388698-226392792 processed_transcript
  ENST00000490921 PARP1-002 226361295-226371115 processed_transcript
  ENST00000491816 PARP1-009 226361410-226362252 processed_transcript
  ENST00000498787 PARP1-006 226365088-226370643 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000366794
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000366794 16.181±0.00 31.375±0.00 2.636±0.00 26.928±16.80 10.856±5.08 14.141±7.15 15.450±12.11 11.837±7.54 10.274±1.82 8.603±5.09 12.872±7.07 19.492±8.89 49.672±13.72 35.537±4.56

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000723 IEA telomere maintenance
GO:0003677 IEA DNA binding
GO:0003950 IDA:IEA NAD+ ADP-ribosyltransferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005635 IDA nuclear envelope
GO:0005654 TAS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005730 IDA nucleolus
GO:0006259 IEA DNA metabolic process
GO:0006281 TAS DNA repair
GO:0006284 IEA base-excision repair
GO:0006302 IMP double-strand break repair
GO:0006351 TAS transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006471 IDA:IEA protein ADP-ribosylation
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0008134 IPI transcription factor binding
GO:0008270 IEA zinc ion binding
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016540 IEA protein autoprocessing
GO:0019899 IPI enzyme binding
GO:0023019 IEA signal transduction involved in regulation of gene expression
GO:0030225 TAS macrophage differentiation
GO:0032869 IDA cellular response to insulin stimulus
GO:0040009 IEA regulation of growth rate
GO:0042769 IEA DNA damage response, detection of DNA damage
GO:0042802 IPI identical protein binding
GO:0043234 IEA protein complex
GO:0044822 IDA poly(A) RNA binding
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0047485 IPI protein N-terminus binding
GO:0051287 IEA NAD binding
GO:0060391 IEA positive regulation of SMAD protein import into nucleus
GO:0070212 IDA protein poly-ADP-ribosylation
GO:0070412 IEA R-SMAD binding
GO:0071451 IEA cellular response to superoxide
GO:2000679 IEA positive regulation of transcription regulatory region DNA binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019529 parp1 poly (ADP-ribose) polymerase family, member 1 protein_coding Danio_rerio
ENSMUSG00000026496 Parp1 poly (ADP-ribose) polymerase family, member 1 protein_coding Mus_musculus

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