C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000145191 EIF2B5 9606 + 3:184135038-184684758 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000273783 EIF2B5-001 184135264-184145310 protein_coding
  ENST00000432569 EIF2B5-003 184135365-184137379 protein_coding
  ENST00000432982 EIF2B5-006 184135400-184142886 nonsense_mediated_decay
  ENST00000444495 EIF2B5-017 184135376-184684758 protein_coding
  ENST00000465218 EIF2B5-005 184142575-184145305 retained_intron
  ENST00000468748 EIF2B5-009 184137939-184140534 retained_intron
  ENST00000471832 EIF2B5-015 184135791-184136979 processed_transcript
  ENST00000479250 EIF2B5-012 184142108-184142871 retained_intron
  ENST00000479833 EIF2B5-016 184138166-184142043 processed_transcript
  ENST00000481054 EIF2B5-004 184135385-184145311 retained_intron
  ENST00000484154 EIF2B5-013 184142797-184143709 retained_intron
  ENST00000491008 EIF2B5-008 184137336-184140154 retained_intron
  ENST00000491144 EIF2B5-002 184135038-184145311 retained_intron
  ENST00000492226 EIF2B5-014 184144054-184144900 retained_intron
  ENST00000492773 EIF2B5-011 184140692-184142886 processed_transcript
  ENST00000493740 EIF2B5-010 184140149-184140908 retained_intron
  ENST00000498831 EIF2B5-007 184135901-184138033 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000273783ENST00000444495ENST00000465218ENST00000479250ENST00000481054ENST00000491008ENST00000491144
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000273783 11.438±0.00 N/A 0.808±0.00 5.288±2.01 5.083±3.50 6.598±3.56 5.807±4.80 8.186±6.74 8.185±0.00 8.392±0.00 11.854±8.27 11.554±4.87 13.799±5.00 6.206±2.98
ENST00000444495 N/A N/A N/A N/A N/A N/A N/A N/A 1.617±0.00 N/A N/A N/A N/A N/A
ENST00000465218 N/A 13.156±0.00 N/A 9.368±0.00 6.672±0.00 7.336±0.00 N/A 9.049±0.00 N/A 4.726±0.00 N/A 16.184±0.00 N/A 4.636±0.13
ENST00000479250 N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.608±0.00 6.095±0.00 66.655±0.00 27.130±0.00 17.819±0.00
ENST00000481054 N/A 6.212±0.00 N/A N/A N/A N/A 0.201±0.00 0.871±0.00 0.725±0.00 1.344±0.00 N/A 6.544±4.98 N/A 3.262±0.00
ENST00000491008 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.861±0.00 N/A N/A N/A N/A
ENST00000491144 N/A N/A N/A N/A 1.408±0.00 1.353±0.00 N/A N/A 0.621±0.00 N/A N/A 1.028±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005G3 CIL_0005G3_0001 CGP 3:184135038-184684758

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001541 IMP ovarian follicle development
GO:0003743 NAS translation initiation factor activity
GO:0005085 ISS guanyl-nucleotide exchange factor activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005851 IDA eukaryotic translation initiation factor 2B complex
GO:0006412 TAS translation
GO:0006413 IDA translational initiation
GO:0006417 IEA regulation of translation
GO:0009408 ISS response to heat
GO:0009749 ISS response to glucose
GO:0010467 TAS gene expression
GO:0014002 IMP astrocyte development
GO:0014003 IMP oligodendrocyte development
GO:0031369 ISS translation initiation factor binding
GO:0032057 ISS negative regulation of translational initiation in response to stress
GO:0034976 IMP response to endoplasmic reticulum stress
GO:0035690 IDA cellular response to drug
GO:0042552 IMP myelination
GO:0043434 ISS response to peptide hormone
GO:0043547 ISS positive regulation of GTPase activity
GO:0044267 TAS cellular protein metabolic process
GO:0045948 ISS positive regulation of translational initiation
GO:0048708 IMP astrocyte differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074995 eif2b5 eukaryotic translation initiation factor 2B, subunit 5 epsilon protein_coding Danio_rerio
ENSDARG00000086151 EIF2B5 (2 of 2) eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa protein_coding Danio_rerio
ENSMUSG00000003235 Eif2b5 eukaryotic translation initiation factor 2B, subunit 5 epsilon protein_coding Mus_musculus

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