C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: calcium/calmodulin-dependent protein kinase II delta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000145349 CAMK2D 9606 - 4:113451032-113761927 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000296402 CAMK2D-201 113451032-113761927 protein_coding
  ENST00000342666 CAMK2D-003 113454105-113761068 protein_coding
  ENST00000379773 CAMK2D-002 113457188-113761130 protein_coding
  ENST00000394522 CAMK2D-004 113456609-113761563 protein_coding
  ENST00000394524 CAMK2D-001 113451032-113761445 protein_coding
  ENST00000505132 CAMK2D-014 113759115-113761451 retained_intron
  ENST00000505990 CAMK2D-005 113457183-113761183 protein_coding
  ENST00000508738 CAMK2D-006 113457331-113761068 protein_coding
  ENST00000509594 CAMK2D-016 113460147-113517643 protein_coding
  ENST00000509907 CAMK2D-015 113754739-113761416 processed_transcript
  ENST00000511664 CAMK2D-008 113454087-113761218 protein_coding
  ENST00000513132 CAMK2D-013 113452961-113513842 protein_coding
  ENST00000514328 CAMK2D-012 113455755-113761068 protein_coding
  ENST00000515496 CAMK2D-009 113455755-113761068 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000296402ENST00000342666ENST00000379773ENST00000394522ENST00000394524ENST00000508738ENST00000511664ENST00000513132ENST00000514328ENST00000515496
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000296402 N/A 1.189±0.00 N/A N/A 2.213±0.00 N/A N/A N/A 1.232±0.00 3.376±0.00 N/A 2.357±0.00 0.542±0.16 N/A
ENST00000342666 N/A N/A 2.223±0.00 N/A 3.118±0.00 5.308±0.00 6.048±0.00 2.232±0.00 3.063±0.00 2.393±0.00 N/A N/A N/A N/A
ENST00000379773 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.818±0.00 N/A
ENST00000394522 N/A N/A N/A 3.757±0.00 2.155±0.00 3.134±0.00 4.603±0.00 N/A 5.876±0.00 2.587±0.00 N/A N/A N/A N/A
ENST00000394524 12.970±0.00 4.865±0.00 N/A 6.080±0.00 3.779±1.54 4.653±2.47 N/A 1.980±0.76 2.418±0.00 4.135±1.48 N/A 4.203±1.48 0.838±0.18 2.500±1.10
ENST00000508738 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.758±0.00 N/A N/A N/A
ENST00000511664 N/A N/A N/A 10.644±0.00 N/A N/A N/A N/A N/A N/A 1.670±0.00 N/A N/A N/A
ENST00000513132 10.677±0.00 N/A 0.937±0.00 6.896±1.91 3.466±0.33 6.136±2.08 5.045±0.00 2.701±0.14 5.379±0.00 4.734±0.93 7.026±0.00 4.396±0.81 0.968±0.04 3.255±0.97
ENST00000514328 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.721±3.15 N/A N/A 2.423±0.00
ENST00000515496 N/A N/A N/A N/A N/A N/A 7.302±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006YO CIL_0006YO_0002 CGP 4:112818109-113761927

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001558 NAS regulation of cell growth
GO:0001666 IEA response to hypoxia
GO:0002026 TAS regulation of the force of heart contraction
GO:0003254 IDA regulation of membrane depolarization
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004683 IDA:IEA calmodulin-dependent protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005516 IPI:IEA calmodulin binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0005954 TAS calcium- and calmodulin-dependent protein kinase complex
GO:0006357 TAS regulation of transcription from RNA polymerase II promoter
GO:0006468 IDA:IEA protein phosphorylation
GO:0007268 TAS synaptic transmission
GO:0008016 TAS regulation of heart contraction
GO:0010389 IEA regulation of G2/M transition of mitotic cell cycle
GO:0010613 IMP positive regulation of cardiac muscle hypertrophy
GO:0010649 ISS regulation of cell communication by electrical coupling
GO:0010880 ISS regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 IC regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0016020 IDA membrane
GO:0016529 IEA sarcoplasmic reticulum
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019871 IDA sodium channel inhibitor activity
GO:0030007 IEA cellular potassium ion homeostasis
GO:0030666 TAS endocytic vesicle membrane
GO:0031432 IPI titin binding
GO:0032469 ISS endoplasmic reticulum calcium ion homeostasis
GO:0034704 ISS calcium channel complex
GO:0035022 IEA positive regulation of Rac protein signal transduction
GO:0042803 IPI protein homodimerization activity
GO:0043234 IEA protein complex
GO:0044325 ISS ion channel binding
GO:0046777 IDA protein autophosphorylation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050998 IEA nitric-oxide synthase binding
GO:0051259 IDA protein oligomerization
GO:0055119 ISS relaxation of cardiac muscle
GO:0060314 TAS regulation of ryanodine-sensitive calcium-release channel activity
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060341 IMP regulation of cellular localization
GO:0061049 IEA cell growth involved in cardiac muscle cell development
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071277 TAS cellular response to calcium ion
GO:0086003 ISS cardiac muscle cell contraction
GO:0086091 IC regulation of heart rate by cardiac conduction
GO:0098901 ISS regulation of cardiac muscle cell action potential
GO:0098909 IC regulation of cardiac muscle cell action potential involved in regulation of contraction
GO:1901725 TAS regulation of histone deacetylase activity
GO:1901844 IC regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901897 IDA regulation of relaxation of cardiac muscle
GO:1902306 IDA negative regulation of sodium ion transmembrane transport
GO:1902514 ISS regulation of generation of L-type calcium current
GO:2000650 IDA negative regulation of sodium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014273 camk2d2 calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2 protein_coding Danio_rerio

Loading