C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: calcium/calmodulin-dependent protein kinase II delta
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000342666 CAMK2D-003 ENSG00000145349 9606 - 4:113454105-113761068 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBreastColonHeartKidneyLiverLungENST00000342666
Transcript ID Bladder Breast Colon Heart Kidney Liver Lung
ENST00000342666 2.223±0.00 3.118±0.00 5.308±0.00 6.048±0.00 2.232±0.00 3.063±0.00 2.393±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006YO CIL_0006YO_0002 CGP 4:112818109-113761927

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001558 NAS regulation of cell growth
GO:0001666 IEA response to hypoxia
GO:0002026 TAS regulation of the force of heart contraction
GO:0003254 IDA regulation of membrane depolarization
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004683 IDA:IEA calmodulin-dependent protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005516 IPI:IEA calmodulin binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0005954 TAS calcium- and calmodulin-dependent protein kinase complex
GO:0006357 TAS regulation of transcription from RNA polymerase II promoter
GO:0006468 IDA:IEA protein phosphorylation
GO:0007268 TAS synaptic transmission
GO:0008016 TAS regulation of heart contraction
GO:0010389 IEA regulation of G2/M transition of mitotic cell cycle
GO:0010613 IMP positive regulation of cardiac muscle hypertrophy
GO:0010649 ISS regulation of cell communication by electrical coupling
GO:0010880 ISS regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 IC regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0016020 IDA membrane
GO:0016529 IEA sarcoplasmic reticulum
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019871 IDA sodium channel inhibitor activity
GO:0030007 IEA cellular potassium ion homeostasis
GO:0030666 TAS endocytic vesicle membrane
GO:0031432 IPI titin binding
GO:0032469 ISS endoplasmic reticulum calcium ion homeostasis
GO:0034704 ISS calcium channel complex
GO:0035022 IEA positive regulation of Rac protein signal transduction
GO:0042803 IPI protein homodimerization activity
GO:0043234 IEA protein complex
GO:0044325 ISS ion channel binding
GO:0046777 IDA protein autophosphorylation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050998 IEA nitric-oxide synthase binding
GO:0051259 IDA protein oligomerization
GO:0055119 ISS relaxation of cardiac muscle
GO:0060314 TAS regulation of ryanodine-sensitive calcium-release channel activity
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060341 IMP regulation of cellular localization
GO:0061049 IEA cell growth involved in cardiac muscle cell development
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071277 TAS cellular response to calcium ion
GO:0086003 ISS cardiac muscle cell contraction
GO:0086091 IC regulation of heart rate by cardiac conduction
GO:0098901 ISS regulation of cardiac muscle cell action potential
GO:0098909 IC regulation of cardiac muscle cell action potential involved in regulation of contraction
GO:1901725 TAS regulation of histone deacetylase activity
GO:1901844 IC regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901897 IDA regulation of relaxation of cardiac muscle
GO:1902306 IDA negative regulation of sodium ion transmembrane transport
GO:1902514 ISS regulation of generation of L-type calcium current
GO:2000650 IDA negative regulation of sodium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000066466 Camk2d-001 protein_coding Mus_musculus 0 2300
ENSMUST00000169051 Camk2d-012 protein_coding Mus_musculus 0 1945
ENSMUST00000106400 Camk2d-018 protein_coding Mus_musculus 0 1943
ENSMUST00000129293 Camk2d-006 retained_intron Mus_musculus 0 1722
ENSMUST00000131869 Camk2d-003 nonsense_mediated_decay Mus_musculus 0 1705
ENSMUST00000145454 Camk2d-004 nonsense_mediated_decay Mus_musculus 0 1471
ENSMUST00000163226 Camk2d-017 protein_coding Mus_musculus 0 1439
ENSMUST00000106399 Camk2d-014 protein_coding Mus_musculus 0 1375
ENSMUST00000106402 Camk2d-002 protein_coding Mus_musculus 0 1375
ENSMUST00000066452 Camk2d-015 protein_coding Mus_musculus 0 1354
ENSMUST00000171289 Camk2d-016 protein_coding Mus_musculus 0 1269
ENSMUST00000106401 Camk2d-008 protein_coding Mus_musculus 0 1269
ENSMUST00000134466 Camk2d-010 nonsense_mediated_decay Mus_musculus 0 843
ENSMUST00000171950 Camk2d-021 processed_transcript Mus_musculus 0 797
ENSMUST00000167417 Camk2d-019 protein_coding Mus_musculus 0 684
ENSDART00000039571 camk2a-201 protein_coding Danio_rerio 0 656
ENSMUST00000170149 Camk2d-022 protein_coding Mus_musculus 0 571
ENSDART00000150983 camk2a-001 protein_coding Danio_rerio 0 542
ENSMUST00000147043 Camk2d-011 retained_intron Mus_musculus 0 538
ENSMUST00000149311 Camk2d-007 retained_intron Mus_musculus 0 481
ENSMUST00000167985 Camk2d-020 protein_coding Mus_musculus 0 364
ENSMUST00000131156 Camk2d-005 retained_intron Mus_musculus 0 329
ENSMUST00000134987 Camk2d-009 retained_intron Mus_musculus 0 283
ENSMUST00000143383 Camk2d-013 processed_transcript Mus_musculus 0 200

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