C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000145545 SRD5A1 9606 + 5:6633343-6669562 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000274192 SRD5A1-001 6633343-6669562 protein_coding
  ENST00000504286 SRD5A1-005 6633456-6653527 processed_transcript
  ENST00000510531 SRD5A1-003 6633427-6668849 nonsense_mediated_decay
  ENST00000513117 SRD5A1-004 6633427-6668972 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000274192ENST00000510531ENST00000513117
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000274192 0.685±0.00 0.847±0.00 2.928±0.03 1.667±0.13 1.027±0.40 0.264±0.14 5.333±2.71 3.252±2.66 0.428±0.00 0.089±0.00 3.631±0.96 0.718±0.04 1.757±0.03
ENST00000510531 N/A N/A N/A N/A 0.208±0.00 N/A N/A N/A N/A N/A N/A 0.148±0.00 N/A
ENST00000513117 N/A N/A N/A N/A N/A N/A N/A 1.991±0.00 0.963±0.00 0.171±0.00 N/A 0.178±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00048P CIL_00048P_0001 CGP 5:6599239-6669562

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003865 IDA:IEA 3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0005737 IEA cytoplasm
GO:0005789 TAS endoplasmic reticulum membrane
GO:0006629 IEA lipid metabolic process
GO:0006702 TAS androgen biosynthetic process
GO:0007530 NAS sex determination
GO:0007548 IEA sex differentiation
GO:0008202 TAS:IEA steroid metabolic process
GO:0009055 TAS electron carrier activity
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016627 IEA oxidoreductase activity, acting on the CH-CH group of donors
GO:0030154 IEA cell differentiation
GO:0044281 TAS small molecule metabolic process
GO:0047751 IEA cholestenone 5-alpha-reductase activity
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020509 srd5a1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) protein_coding Danio_rerio
ENSMUSG00000021594 Srd5a1 steroid 5 alpha-reductase 1 protein_coding Mus_musculus

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