C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: corticotropin releasing hormone
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000147571 CRH 9606 - 8:66176382-66178725 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000276571 CRH-001 66176382-66178725 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainBreastOvaryPlacentaTestisENST00000276571
Transcript ID Brain Breast Ovary Placenta Testis
ENST00000276571 0.789±0.15 0.045±0.00 0.028±0.00 45.790±31.88 0.191±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005BV CIL_0005BV_0002 CGP 8:66126896-66178725

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0001963 IDA synaptic transmission, dopaminergic
GO:0005102 TAS receptor binding
GO:0005179 TAS:IEA hormone activity
GO:0005184 TAS neuropeptide hormone activity
GO:0005515 IPI protein binding
GO:0005576 TAS:IEA extracellular region
GO:0005615 IDA extracellular space
GO:0005737 IEA cytoplasm
GO:0006704 IEA glucocorticoid biosynthetic process
GO:0006954 IDA inflammatory response
GO:0007165 TAS signal transduction
GO:0007268 TAS synaptic transmission
GO:0007565 IDA female pregnancy
GO:0007567 TAS parturition
GO:0007611 TAS learning or memory
GO:0007616 IEA long-term memory
GO:0007631 IEA feeding behavior
GO:0008202 IEA steroid metabolic process
GO:0008284 IEA positive regulation of cell proliferation
GO:0008306 IEA associative learning
GO:0008628 IEA hormone-mediated apoptotic signaling pathway
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010700 IEA negative regulation of norepinephrine secretion
GO:0010841 NAS positive regulation of circadian sleep/wake cycle, wakefulness
GO:0010942 IEA positive regulation of cell death
GO:0014062 IEA regulation of serotonin secretion
GO:0016101 IEA diterpenoid metabolic process
GO:0017045 IEA corticotropin-releasing hormone activity
GO:0021854 IEA hypothalamus development
GO:0030324 IEA lung development
GO:0030325 IEA adrenal gland development
GO:0030819 IEA positive regulation of cAMP biosynthetic process
GO:0032811 IEA negative regulation of epinephrine secretion
GO:0033685 IEA negative regulation of luteinizing hormone secretion
GO:0035641 IEA locomotory exploration behavior
GO:0035774 IEA positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035902 IEA response to immobilization stress
GO:0042220 IEA response to cocaine
GO:0042322 NAS negative regulation of circadian sleep/wake cycle, REM sleep
GO:0042493 IEA response to drug
GO:0043025 IEA neuronal cell body
GO:0043196 IEA varicosity
GO:0043204 IEA perikaryon
GO:0043627 IEA response to estrogen
GO:0045471 IEA response to ethanol
GO:0045472 IEA response to ether
GO:0045776 IEA negative regulation of blood pressure
GO:0048265 IEA response to pain
GO:0050801 IEA ion homeostasis
GO:0051412 IEA response to corticosterone
GO:0051430 IEA corticotropin-releasing hormone receptor 1 binding
GO:0051431 IEA corticotropin-releasing hormone receptor 2 binding
GO:0051461 IEA positive regulation of corticotropin secretion
GO:0051464 IDA positive regulation of cortisol secretion
GO:0051602 IEA response to electrical stimulus
GO:0060291 IEA long-term synaptic potentiation
GO:0060456 IEA positive regulation of digestive system process
GO:0060548 IEA negative regulation of cell death
GO:0070093 IEA negative regulation of glucagon secretion
GO:0071314 IEA cellular response to cocaine
GO:0071549 IEA cellular response to dexamethasone stimulus
GO:0090280 IEA positive regulation of calcium ion import
GO:2000310 IDA regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000854 IEA positive regulation of corticosterone secretion
GO:2000987 IEA positive regulation of behavioral fear response

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027657 crhb corticotropin releasing hormone b protein_coding Danio_rerio
ENSDARG00000093401 crha corticotropin releasing hormone a protein_coding Danio_rerio
ENSMUSG00000049796 Crh corticotropin releasing hormone protein_coding Mus_musculus

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