C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: notch 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000148400 NOTCH1 9606 - 9:136494444-136545862 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000277541 NOTCH1-001 136494444-136545862 protein_coding
  ENST00000491649 NOTCH1-003 136522628-136523898 processed_transcript
  ENST00000494783 NOTCH1-002 136502446-136504845 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000277541
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000277541 13.060±0.00 8.362±0.00 1.949±1.32 6.834±4.08 9.612±0.00 1.780±0.86 2.422±1.21 1.876±0.40 9.403±0.00 1.040±0.34 4.527±2.95 4.290±1.85 2.389±1.24

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003X5 CIL_0003X5_0001 CGP 9:136494444-136672678

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000139 TAS Golgi membrane
GO:0001047 ISS core promoter binding
GO:0001190 ISS RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001669 IEA acrosomal vesicle
GO:0001701 IEA in utero embryonic development
GO:0001708 IEA cell fate specification
GO:0001837 ISS epithelial to mesenchymal transition
GO:0001889 IEA liver development
GO:0001947 ISS heart looping
GO:0002040 IEA sprouting angiogenesis
GO:0002052 IEA positive regulation of neuroblast proliferation
GO:0002193 IDA MAML1-RBP-Jkappa- ICN1 complex
GO:0002437 IEA inflammatory response to antigenic stimulus
GO:0003157 ISS endocardium development
GO:0003160 ISS endocardium morphogenesis
GO:0003162 IEA atrioventricular node development
GO:0003169 ISS coronary vein morphogenesis
GO:0003180 IMP aortic valve morphogenesis
GO:0003181 ISS atrioventricular valve morphogenesis
GO:0003184 IMP pulmonary valve morphogenesis
GO:0003192 IMP mitral valve formation
GO:0003198 ISS epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 ISS endocardial cushion morphogenesis
GO:0003207 ISS cardiac chamber formation
GO:0003208 ISS cardiac ventricle morphogenesis
GO:0003209 ISS cardiac atrium morphogenesis
GO:0003213 ISS cardiac right atrium morphogenesis
GO:0003214 ISS cardiac left ventricle morphogenesis
GO:0003219 IEA cardiac right ventricle formation
GO:0003222 ISS ventricular trabecula myocardium morphogenesis
GO:0003241 ISS growth involved in heart morphogenesis
GO:0003256 ISS regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003264 IEA regulation of cardioblast proliferation
GO:0003270 IEA Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0003273 ISS cell migration involved in endocardial cushion formation
GO:0003344 ISS pericardium morphogenesis
GO:0003682 IEA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0004857 ISS enzyme inhibitor activity
GO:0004872 IEA receptor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS extracellular region
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006355 TAS regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006955 NAS immune response
GO:0006959 IEA humoral immune response
GO:0007219 TAS:IEA Notch signaling pathway
GO:0007220 TAS Notch receptor processing
GO:0007221 ISS positive regulation of transcription of Notch receptor target
GO:0007275 IEA multicellular organismal development
GO:0007283 IEA spermatogenesis
GO:0007368 ISS determination of left/right symmetry
GO:0007386 IEA compartment pattern specification
GO:0007409 IEA axonogenesis
GO:0007420 IEA brain development
GO:0007440 IEA foregut morphogenesis
GO:0007492 IEA endoderm development
GO:0007507 IMP heart development
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0008544 IEA epidermis development
GO:0009912 IEA auditory receptor cell fate commitment
GO:0009986 IEA cell surface
GO:0010001 IEA glial cell differentiation
GO:0010467 TAS gene expression
GO:0010468 IEA regulation of gene expression
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0010812 IDA negative regulation of cell-substrate adhesion
GO:0010832 ISS negative regulation of myotube differentiation
GO:0014031 ISS mesenchymal cell development
GO:0014807 IEA regulation of somitogenesis
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019899 ISS enzyme binding
GO:0021515 IEA cell differentiation in spinal cord
GO:0021915 IEA neural tube development
GO:0030154 IEA cell differentiation
GO:0030182 IEA neuron differentiation
GO:0030216 IEA keratinocyte differentiation
GO:0030279 ISS negative regulation of ossification
GO:0030324 IEA lung development
GO:0030326 IEA embryonic limb morphogenesis
GO:0030334 IEA regulation of cell migration
GO:0030335 ISS positive regulation of cell migration
GO:0030513 ISS positive regulation of BMP signaling pathway
GO:0030514 ISS negative regulation of BMP signaling pathway
GO:0030900 IEA forebrain development
GO:0031069 IEA hair follicle morphogenesis
GO:0031100 IEA organ regeneration
GO:0031490 IEA chromatin DNA binding
GO:0031960 IEA response to corticosteroid
GO:0032495 IEA response to muramyl dipeptide
GO:0032496 IEA response to lipopolysaccharide
GO:0035116 IEA embryonic hindlimb morphogenesis
GO:0035148 IMP tube formation
GO:0035914 IEA skeletal muscle cell differentiation
GO:0035924 IDA cellular response to vascular endothelial growth factor stimulus
GO:0042127 IEA regulation of cell proliferation
GO:0042246 IEA tissue regeneration
GO:0043065 IEA positive regulation of apoptotic process
GO:0043086 ISS negative regulation of catalytic activity
GO:0043235 IDA receptor complex
GO:0043565 IEA sequence-specific DNA binding
GO:0045165 IEA cell fate commitment
GO:0045596 IEA negative regulation of cell differentiation
GO:0045603 IEA positive regulation of endothelial cell differentiation
GO:0045618 IEA positive regulation of keratinocyte differentiation
GO:0045662 IMP negative regulation of myoblast differentiation
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045668 ISS negative regulation of osteoblast differentiation
GO:0045687 IEA positive regulation of glial cell differentiation
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0045955 IEA negative regulation of calcium ion-dependent exocytosis
GO:0046427 ISS positive regulation of JAK-STAT cascade
GO:0046533 IEA negative regulation of photoreceptor cell differentiation
GO:0048103 IEA somatic stem cell division
GO:0048663 IEA neuron fate commitment
GO:0048708 IEA astrocyte differentiation
GO:0048709 IEA oligodendrocyte differentiation
GO:0048711 ISS positive regulation of astrocyte differentiation
GO:0048715 ISS negative regulation of oligodendrocyte differentiation
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0050678 IEA regulation of epithelial cell proliferation
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0050767 IEA regulation of neurogenesis
GO:0050768 ISS negative regulation of neurogenesis
GO:0050793 IEA regulation of developmental process
GO:0055008 ISS cardiac muscle tissue morphogenesis
GO:0060038 IEA cardiac muscle cell proliferation
GO:0060045 ISS positive regulation of cardiac muscle cell proliferation
GO:0060253 ISS negative regulation of glial cell proliferation
GO:0060271 ISS cilium morphogenesis
GO:0060317 ISS cardiac epithelial to mesenchymal transition
GO:0060411 ISS cardiac septum morphogenesis
GO:0060412 IMP ventricular septum morphogenesis
GO:0060528 IEA secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060548 IEA negative regulation of cell death
GO:0060740 IEA prostate gland epithelium morphogenesis
GO:0060768 IEA regulation of epithelial cell proliferation involved in prostate gland development
GO:0060842 ISS arterial endothelial cell differentiation
GO:0060843 ISS venous endothelial cell differentiation
GO:0060948 ISS cardiac vascular smooth muscle cell development
GO:0060956 ISS endocardial cell differentiation
GO:0060979 ISS vasculogenesis involved in coronary vascular morphogenesis
GO:0060982 ISS coronary artery morphogenesis
GO:0061314 IMP Notch signaling involved in heart development
GO:0061384 ISS heart trabecula morphogenesis
GO:0061419 ISS positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070986 IEA left/right axis specification
GO:0071372 IDA cellular response to follicle-stimulating hormone stimulus
GO:0071944 IEA cell periphery
GO:0072017 IEA distal tubule development
GO:0072044 IEA collecting duct development
GO:0072144 IEA glomerular mesangial cell development
GO:0072602 IEA interleukin-4 secretion
GO:0090051 IDA negative regulation of cell migration involved in sprouting angiogenesis
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:0097150 IEP neuronal stem cell maintenance
GO:1901201 ISS regulation of extracellular matrix assembly
GO:1902263 IEA apoptotic process involved in embryonic digit morphogenesis
GO:2000737 IMP negative regulation of stem cell differentiation
GO:2000811 IMP negative regulation of anoikis
GO:2000974 ISS negative regulation of pro-B cell differentiation
GO:2001027 IDA negative regulation of endothelial cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044841 notch1a notch homolog 1a protein_coding Danio_rerio
ENSDARG00000052094 notch1b notch homolog 1b protein_coding Danio_rerio
ENSMUSG00000026923 Notch1 notch 1 protein_coding Mus_musculus

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