C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adrenoceptor alpha 2A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000150594 ADRA2A 9606 + 10:111077163-111080907 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000280155 ADRA2A-001 111077163-111080907 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000280155
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000280155 22.200±0.00 21.218±0.00 0.148±0.00 1.413±0.21 22.867±21.58 2.371±1.83 0.228±0.14 0.750±0.00 0.739±0.25 1.536±0.62 0.207±0.16 7.324±7.21 2.996±0.49 6.253±1.11

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006FA CIL_0006FA_0001 CGP 10:110919547-111080907
CIL_0006FB CIL_0006FB_0001 CGP 10:111077163-112215377

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001819 IDA positive regulation of cytokine production
GO:0002526 IEA acute inflammatory response
GO:0004930 IEA G-protein coupled receptor activity
GO:0004935 IEA adrenergic receptor activity
GO:0004938 IDA alpha2-adrenergic receptor activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006112 TAS energy reserve metabolic process
GO:0006260 IEA DNA replication
GO:0006928 TAS cellular component movement
GO:0007165 TAS signal transduction
GO:0007186 ISS:IEA G-protein coupled receptor signaling pathway
GO:0007194 ISS negative regulation of adenylate cyclase activity
GO:0007265 TAS Ras protein signal transduction
GO:0007266 TAS Rho protein signal transduction
GO:0007565 IEA female pregnancy
GO:0007596 TAS blood coagulation
GO:0008284 TAS positive regulation of cell proliferation
GO:0010700 NAS negative regulation of norepinephrine secretion
GO:0016021 IEA integral component of membrane
GO:0016323 TAS basolateral plasma membrane
GO:0019229 IEA regulation of vasoconstriction
GO:0019901 IPI protein kinase binding
GO:0030036 TAS actin cytoskeleton organization
GO:0030168 TAS platelet activation
GO:0030335 IMP positive regulation of cell migration
GO:0030818 ISS negative regulation of cAMP biosynthetic process
GO:0031692 ISS alpha-1B adrenergic receptor binding
GO:0031696 IPI alpha-2C adrenergic receptor binding
GO:0031996 IPI thioesterase binding
GO:0032147 IDA activation of protein kinase activity
GO:0032148 IDA activation of protein kinase B activity
GO:0032795 IDA heterotrimeric G-protein binding
GO:0032811 NAS negative regulation of epinephrine secretion
GO:0032870 IGI cellular response to hormone stimulus
GO:0035625 IDA epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0042593 IMP glucose homeostasis
GO:0042596 IEA fear response
GO:0042803 IDA protein homodimerization activity
GO:0043235 IDA receptor complex
GO:0043268 ISS positive regulation of potassium ion transport
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0044281 TAS small molecule metabolic process
GO:0045202 IEA synapse
GO:0045741 IDA positive regulation of epidermal growth factor-activated receptor activity
GO:0045909 IEA positive regulation of vasodilation
GO:0045955 IC negative regulation of calcium ion-dependent exocytosis
GO:0046676 IMP negative regulation of insulin secretion
GO:0046982 ISS protein heterodimerization activity
GO:0050796 TAS regulation of insulin secretion
GO:0050892 TAS intestinal absorption
GO:0050955 IEA thermoception
GO:0050995 IGI negative regulation of lipid catabolic process
GO:0051044 IDA positive regulation of membrane protein ectodomain proteolysis
GO:0051379 IDA epinephrine binding
GO:0051380 IDA norepinephrine binding
GO:0051926 ISS negative regulation of calcium ion transport
GO:0061179 IMP negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070473 IEA negative regulation of uterine smooth muscle contraction
GO:0071878 ISS negative regulation of adrenergic receptor signaling pathway
GO:0071881 IDA adenylate cyclase-inhibiting adrenergic receptor signaling pathway
GO:0071882 IDA phospholipase C-activating adrenergic receptor signaling pathway
GO:0071883 IDA activation of MAPK activity by adrenergic receptor signaling pathway
GO:0090303 IMP positive regulation of wound healing
GO:1901020 ISS negative regulation of calcium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040841 adra2a adrenergic, alpha-2A-, receptor protein_coding Danio_rerio
ENSMUSG00000033717 Adra2a adrenergic receptor, alpha 2a protein_coding Mus_musculus

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