C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: aldo-keto reductase family 1, member C2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000151632 AKR1C2 9606 - 10:4922564-5135226 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000380753 AKR1C2-001 4987400-5004023 protein_coding
  ENST00000407674 AKR1C2-201 4922564-5135226 protein_coding
  ENST00000421196 AKR1C2-003 4989434-5003860 protein_coding
  ENST00000455190 AKR1C2-202 4999911-5004014 protein_coding
  ENST00000460124 AKR1C2-002 4989789-5004023 retained_intron
  ENST00000603073 AKR1C2-006 5010463-5015892 processed_transcript
  ENST00000604184 AKR1C2-005 5000303-5003861 processed_transcript
  ENST00000604428 AKR1C2-008 5005995-5018031 processed_transcript
  ENST00000604439 AKR1C2-004 5013307-5015048 processed_transcript
  ENST00000604507 AKR1C2-007 4995834-5017955 protein_coding
  ENST00000604711 AKR1C2-009 5006462-5017934 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000380753ENST00000407674ENST00000421196ENST00000460124ENST00000604184ENST00000604507
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000380753 1.107±0.00 0.635±0.00 0.064±0.00 N/A 5.700±5.37 0.764±0.00 0.110±0.00 1.220±0.00 3.106±0.00 N/A N/A 0.142±0.03 0.035±0.01 0.283±0.14
ENST00000407674 5.122±0.00 3.615±0.00 N/A 0.361±0.10 19.094±17.84 2.111±0.87 0.723±0.00 6.916±0.00 9.532±5.55 1.583±0.00 1.003±0.00 1.597±0.33 0.173±0.13 2.098±0.62
ENST00000421196 11.524±0.00 4.747±0.00 0.377±0.00 0.399±0.10 42.297±41.63 1.585±0.64 0.801±0.01 7.056±3.42 11.894±4.21 2.182±0.00 2.506±1.25 0.726±0.28 0.090±0.02 2.371±1.19
ENST00000460124 N/A N/A 0.239±0.00 N/A N/A 1.225±0.00 0.233±0.00 N/A 1.637±0.00 N/A N/A N/A N/A N/A
ENST00000604184 N/A N/A N/A N/A 4.245±0.00 N/A N/A N/A N/A N/A N/A 1.299±0.00 N/A N/A
ENST00000604507 15.945±0.00 6.840±0.00 N/A 0.930±0.52 56.570±54.04 1.758±0.00 1.867±0.00 12.808±8.13 14.645±9.34 3.755±0.00 2.951±1.13 1.222±0.34 0.136±0.00 5.223±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002HN CIL_0002HN_0001 CGP 10:4922564-5135226

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004032 IDA alditol:NADP+ 1-oxidoreductase activity
GO:0004958 IDA prostaglandin F receptor activity
GO:0005737 IEA cytoplasm
GO:0006693 IDA prostaglandin metabolic process
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007586 IDA digestion
GO:0008202 IDA steroid metabolic process
GO:0008284 IDA positive regulation of cell proliferation
GO:0016491 IEA oxidoreductase activity
GO:0016655 IDA oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018636 IDA phenanthrene 9,10-monooxygenase activity
GO:0030855 IEP epithelial cell differentiation
GO:0031406 IDA carboxylic acid binding
GO:0032052 IDA bile acid binding
GO:0034694 IDA response to prostaglandin
GO:0042448 IDA progesterone metabolic process
GO:0044597 IMP daunorubicin metabolic process
GO:0044598 IMP doxorubicin metabolic process
GO:0047086 IDA ketosteroid monooxygenase activity
GO:0047115 IDA trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0055114 IEA:IDA oxidation-reduction process
GO:0071395 IDA cellular response to jasmonic acid stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000021207 Akr1c21 aldo-keto reductase family 1, member C21 protein_coding Mus_musculus
ENSMUSG00000021210 Akr1c6 aldo-keto reductase family 1, member C6 protein_coding Mus_musculus
ENSMUSG00000021214 Akr1c18 aldo-keto reductase family 1, member C18 protein_coding Mus_musculus
ENSMUSG00000025955 Akr1cl aldo-keto reductase family 1, member C-like protein_coding Mus_musculus
ENSMUSG00000033715 Akr1c14 aldo-keto reductase family 1, member C14 protein_coding Mus_musculus
ENSMUSG00000054757 Akr1c20 aldo-keto reductase family 1, member C20 protein_coding Mus_musculus

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