C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: gap junction protein, alpha 1, 43kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000152661 GJA1 9606 + 6:121435692-121449727 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000282561 GJA1-001 121435692-121449727 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000282561
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000282561 38.835±0.00 24.154±0.00 2.892±0.00 85.741±33.17 25.585±12.58 20.171±13.34 35.322±10.78 5.541±5.24 15.769±15.19 50.586±34.02 2.027±0.80 39.069±29.47 96.109±31.67 19.904±3.66

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0001649 IEA osteoblast differentiation
GO:0001701 IEA in utero embryonic development
GO:0001764 IEA neuron migration
GO:0001937 IEA negative regulation of endothelial cell proliferation
GO:0001947 IEA heart looping
GO:0002070 IEA epithelial cell maturation
GO:0002088 IEA lens development in camera-type eye
GO:0002544 IEA chronic inflammatory response
GO:0003104 IEA positive regulation of glomerular filtration
GO:0003158 IEA endothelium development
GO:0003294 IEA atrial ventricular junction remodeling
GO:0004871 IMP signal transducer activity
GO:0005102 IEA receptor binding
GO:0005243 IDA gap junction channel activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005741 IEA mitochondrial outer membrane
GO:0005764 IEA lysosome
GO:0005768 IEA endosome
GO:0005769 IEA early endosome
GO:0005770 IEA late endosome
GO:0005771 IEA multivesicular body
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005794 ISS Golgi apparatus
GO:0005829 IEA cytosol
GO:0005882 IEA intermediate filament
GO:0005886 ISS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005916 IEA fascia adherens
GO:0005921 ISS gap junction
GO:0005922 IEA connexon complex
GO:0005925 IDA focal adhesion
GO:0006810 TAS transport
GO:0006915 IEA apoptotic process
GO:0006936 TAS muscle contraction
GO:0007154 IEA cell communication
GO:0007165 IMP signal transduction
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007267 TAS cell-cell signaling
GO:0007507 TAS heart development
GO:0007512 IEA adult heart development
GO:0008016 IEA regulation of heart contraction
GO:0008285 IEA negative regulation of cell proliferation
GO:0009268 IEA response to pH
GO:0009749 IEA response to glucose
GO:0010232 IEA vascular transport
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010643 IEA cell communication by chemical coupling
GO:0010644 IDA cell communication by electrical coupling
GO:0010652 IEA positive regulation of cell communication by chemical coupling
GO:0014704 ISS intercalated disc
GO:0015075 TAS ion transmembrane transporter activity
GO:0015867 IEA ATP transport
GO:0016020 IEA membrane
GO:0016264 TAS gap junction assembly
GO:0016324 IEA apical plasma membrane
GO:0016328 IEA lateral plasma membrane
GO:0017124 IEA SH3 domain binding
GO:0019904 IEA protein domain specific binding
GO:0030054 IEA cell junction
GO:0030165 IEA PDZ domain binding
GO:0030500 IEA regulation of bone mineralization
GO:0030660 TAS Golgi-associated vesicle membrane
GO:0032024 IEA positive regulation of insulin secretion
GO:0034220 TAS ion transmembrane transport
GO:0034405 IEA response to fluid shear stress
GO:0035050 IEA embryonic heart tube development
GO:0042733 IEA embryonic digit morphogenesis
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043292 IEA contractile fiber
GO:0043403 IEA skeletal muscle tissue regeneration
GO:0043434 IEA response to peptide hormone
GO:0045121 ISS membrane raft
GO:0045216 IEA cell-cell junction organization
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045732 IEA positive regulation of protein catabolic process
GO:0045844 IEA positive regulation of striated muscle tissue development
GO:0045907 IEA positive regulation of vasoconstriction
GO:0045909 IEA positive regulation of vasodilation
GO:0046850 IEA regulation of bone remodeling
GO:0048487 IEA beta-tubulin binding
GO:0048514 IEA blood vessel morphogenesis
GO:0048812 IEA neuron projection morphogenesis
GO:0051259 IEA protein oligomerization
GO:0051924 IEA regulation of calcium ion transport
GO:0055085 IDA transmembrane transport
GO:0060044 IEA negative regulation of cardiac muscle cell proliferation
GO:0060156 IEA milk ejection
GO:0060307 IEA regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371 IEA regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373 IEA regulation of ventricular cardiac muscle cell membrane depolarization
GO:0061024 TAS membrane organization
GO:0061045 IEA negative regulation of wound healing
GO:0061337 IEA cardiac conduction
GO:0070062 IDA extracellular vesicular exosome
GO:0071253 IEA connexin binding
GO:0071260 IEA cellular response to mechanical stimulus
GO:0086014 TAS atrial cardiac muscle cell action potential
GO:0097110 IEA scaffold protein binding
GO:2000279 IEA negative regulation of DNA biosynthetic process
GO:2000810 IEA regulation of tight junction assembly
GO:2000987 IEA positive regulation of behavioral fear response

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041799 cx43 connexin 43 protein_coding Danio_rerio
ENSDARG00000071192 cx40.8 connexin 40.8 protein_coding Danio_rerio
ENSMUSG00000050953 Gja1 gap junction protein, alpha 1 protein_coding Mus_musculus

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