C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: xanthine dehydrogenase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000158125 XDH 9606 - 2:31334321-31414715 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000379416 XDH-001 31334321-31414715 protein_coding
  ENST00000476043 XDH-003 31383082-31384395 processed_transcript
  ENST00000491727 XDH-002 31383001-31389633 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000379416ENST00000476043ENST00000491727
Transcript ID Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000379416 0.008±0.00 0.006±0.00 0.435±0.00 0.865±0.69 0.006±0.00 16.795±0.00 1.727±1.64 0.027±0.00 0.357±0.28 0.075±0.00 0.186±0.14
ENST00000476043 N/A N/A N/A N/A 0.021±0.00 N/A N/A 0.075±0.00 N/A N/A N/A
ENST00000491727 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.088±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000VD CIL_0000VD_0001 CGP 2:31234337-31414715
CIL_0000VC CIL_0000VC_0001 CGP 2:31334321-31581067

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001933 IDA negative regulation of protein phosphorylation
GO:0001937 IDA negative regulation of endothelial cell proliferation
GO:0003824 IEA catalytic activity
GO:0004854 IDA:IEA xanthine dehydrogenase activity
GO:0004855 IDA:IEA xanthine oxidase activity
GO:0005506 IEA iron ion binding
GO:0005515 IEA protein binding
GO:0005615 IDA extracellular space
GO:0005777 IEA peroxisome
GO:0005829 TAS cytosol
GO:0006144 TAS purine nucleobase metabolic process
GO:0006195 TAS purine nucleotide catabolic process
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007595 IEA lactation
GO:0008762 IEA UDP-N-acetylmuramate dehydrogenase activity
GO:0009055 IEA electron carrier activity
GO:0009115 IDA xanthine catabolic process
GO:0010629 IDA negative regulation of gene expression
GO:0016491 IEA oxidoreductase activity
GO:0016614 IEA oxidoreductase activity, acting on CH-OH group of donors
GO:0030856 IEA regulation of epithelial cell differentiation
GO:0042803 IPI protein homodimerization activity
GO:0043546 IDA molybdopterin cofactor binding
GO:0044281 TAS small molecule metabolic process
GO:0045602 IDA negative regulation of endothelial cell differentiation
GO:0046872 IEA metal ion binding
GO:0050660 IDA:IEA flavin adenine dinucleotide binding
GO:0051536 IEA iron-sulfur cluster binding
GO:0051537 IDA 2 iron, 2 sulfur cluster binding
GO:0051898 IDA negative regulation of protein kinase B signaling
GO:0055086 TAS nucleobase-containing small molecule metabolic process
GO:0055114 IEA oxidation-reduction process
GO:1900745 IDA positive regulation of p38MAPK cascade
GO:1900747 IDA negative regulation of vascular endothelial growth factor signaling pathway
GO:2000379 IDA positive regulation of reactive oxygen species metabolic process
GO:2001213 IDA negative regulation of vasculogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055240 xdh xanthine dehydrogenase protein_coding Danio_rerio
ENSMUSG00000024066 Xdh xanthine dehydrogenase protein_coding Mus_musculus

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