C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase, AMP-activated, alpha 2 catalytic subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000162409 PRKAA2 9606 + 1:56645322-56715335 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000371244 PRKAA2-001 56645322-56715335 protein_coding
  ENST00000610361 PRKAA2-201 56645388-56715334 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000371244ENST00000610361
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000371244 0.422±0.00 0.786±0.00 2.182±0.00 2.324±0.89 0.964±0.55 2.037±0.24 18.082±6.05 4.477±0.00 1.288±1.23 0.462±0.17 14.985±9.13 0.801±0.15 0.095±0.08 0.967±0.00
ENST00000610361 N/A 0.362±0.00 N/A N/A 0.419±0.00 N/A N/A N/A 0.060±0.00 0.287±0.00 N/A 0.777±0.19 0.073±0.00 0.714±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00005E CIL_00005E_0002 CGP 1:56494747-56715335

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003682 ISS chromatin binding
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004679 IDA AMP-activated protein kinase activity
GO:0004712 IDA protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006112 TAS energy reserve metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 TAS:IEA protein phosphorylation
GO:0006633 IEA fatty acid biosynthetic process
GO:0006695 IEA cholesterol biosynthetic process
GO:0006853 TAS carnitine shuttle
GO:0006914 IEA autophagy
GO:0006950 ISS response to stress
GO:0007050 TAS cell cycle arrest
GO:0007165 TAS signal transduction
GO:0008286 TAS insulin receptor signaling pathway
GO:0008610 ISS lipid biosynthetic process
GO:0010508 ISS positive regulation of autophagy
GO:0016055 IEA Wnt signaling pathway
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0031669 ISS cellular response to nutrient levels
GO:0032007 ISS negative regulation of TOR signaling
GO:0035174 ISS histone serine kinase activity
GO:0035404 IEA histone-serine phosphorylation
GO:0042149 ISS cellular response to glucose starvation
GO:0042304 TAS regulation of fatty acid biosynthetic process
GO:0042593 ISS glucose homeostasis
GO:0042752 ISS regulation of circadian rhythm
GO:0043066 ISS negative regulation of apoptotic process
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045821 ISS positive regulation of glycolytic process
GO:0046872 IEA metal ion binding
GO:0047322 IEA [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0048511 IEA rhythmic process
GO:0050405 IEA [acetyl-CoA carboxylase] kinase activity
GO:0055089 ISS fatty acid homeostasis
GO:0061024 TAS membrane organization
GO:2000505 ISS regulation of energy homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060641 prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit protein_coding Danio_rerio
ENSMUSG00000028518 Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit protein_coding Mus_musculus

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