C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase-activated protein kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000162889 MAPKAPK2 9606 + 1:206684944-206734283 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000294981 MAPKAPK2-002 206684944-206732863 protein_coding
  ENST00000367103 MAPKAPK2-001 206685037-206734283 protein_coding
  ENST00000479009 MAPKAPK2-004 206731288-206732116 processed_transcript
  ENST00000493447 MAPKAPK2-003 206728934-206729470 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000294981ENST00000367103
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000294981 N/A N/A 3.725±0.00 N/A 1.824±0.00 1.251±0.00 1.382±0.00 0.927±0.00 1.537±0.00 1.478±0.00 N/A 1.448±0.00 N/A N/A
ENST00000367103 40.516±0.00 46.173±0.00 N/A 7.890±6.22 16.357±12.16 14.713±11.10 43.844±35.76 26.794±24.90 9.602±6.17 37.850±33.61 33.766±18.42 24.955±12.20 17.691±5.90 29.871±0.04

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 TAS MAPK cascade
GO:0000187 TAS activation of MAPK activity
GO:0002224 ISS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004871 TAS signal transducer activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0006468 TAS:IEA protein phosphorylation
GO:0006691 TAS leukotriene metabolic process
GO:0006950 IDA response to stress
GO:0006954 ISS inflammatory response
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0007265 TAS Ras protein signal transduction
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0010467 TAS gene expression
GO:0016020 IEA membrane
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019369 TAS arachidonic acid metabolic process
GO:0031572 IMP G2 DNA damage checkpoint
GO:0032496 ISS response to lipopolysaccharide
GO:0032675 ISS regulation of interleukin-6 production
GO:0032680 IDA regulation of tumor necrosis factor production
GO:0034097 IDA response to cytokine
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035924 IMP cellular response to vascular endothelial growth factor stimulus
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0044281 TAS small molecule metabolic process
GO:0044351 ISS macropinocytosis
GO:0045087 TAS innate immune response
GO:0048010 IMP vascular endothelial growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048255 IEA mRNA stabilization
GO:0048839 IEA inner ear development
GO:0051403 TAS stress-activated MAPK cascade
GO:0070935 IDA 3'-UTR-mediated mRNA stabilization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002552 mapkapk2a mitogen-activated protein kinase-activated protein kinase 2a protein_coding Danio_rerio
ENSDARG00000018530 mapkapk2b mitogen-activated protein kinase-activated protein kinase 2b protein_coding Danio_rerio
ENSMUSG00000016528 Mapkapk2 MAP kinase-activated protein kinase 2 protein_coding Mus_musculus

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