C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MAP kinase-activated protein kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000016528 Mapkapk2 10090 - 1:131053700-131097826 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000016672 Mapkapk2-001 131053700-131097826 protein_coding
  ENSMUST00000188459 Mapkapk2-002 131056889-131072526 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000016672
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000016672 42.089±10.32 69.204±10.17 24.454±3.73 10.190±4.35 41.509±3.36 36.614±2.58 66.440±18.67 38.845±5.50 14.636±4.93 51.019±3.68 76.647±10.37 44.947±10.99 27.457±9.22 5.617±1.77

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001SF CIL_0001SF_0002 CGP 1:131019845-131097826
CIL_0004IS CIL_0004IS_0002 CGP 1:131053700-131138340

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002224 IMP toll-like receptor signaling pathway
GO:0004674 IDA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005813 IEA centrosome
GO:0006468 IDA protein phosphorylation
GO:0006950 IEA response to stress
GO:0006954 IMP inflammatory response
GO:0006974 ISS cellular response to DNA damage stimulus
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0031572 ISS G2 DNA damage checkpoint
GO:0032496 IMP response to lipopolysaccharide
GO:0032675 IMP regulation of interleukin-6 production
GO:0032680 ISS regulation of tumor necrosis factor production
GO:0034097 ISS response to cytokine
GO:0035924 IEA cellular response to vascular endothelial growth factor stimulus
GO:0044351 IMP macropinocytosis
GO:0048010 IEA vascular endothelial growth factor receptor signaling pathway
GO:0048255 IMP mRNA stabilization
GO:0048839 IDA inner ear development
GO:0070935 ISS 3'-UTR-mediated mRNA stabilization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002552 mapkapk2a mitogen-activated protein kinase-activated protein kinase 2a protein_coding Danio_rerio
ENSDARG00000018530 mapkapk2b mitogen-activated protein kinase-activated protein kinase 2b protein_coding Danio_rerio
ENSG00000162889 MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 protein_coding Homo_sapiens

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