C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000163636 PSMD6 9606 - 3:64010549-64024010 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000295901 PSMD6-001 64010549-64023560 protein_coding
  ENST00000394431 PSMD6-201 64010550-64024010 protein_coding
  ENST00000463139 PSMD6-006 64010555-64013288 retained_intron
  ENST00000467853 PSMD6-005 64010554-64017732 retained_intron
  ENST00000475036 PSMD6-007 64018663-64023478 retained_intron
  ENST00000476464 PSMD6-004 64010555-64023437 retained_intron
  ENST00000478185 PSMD6-009 64019424-64023456 protein_coding
  ENST00000480205 PSMD6-011 64010554-64019334 protein_coding
  ENST00000482510 PSMD6-003 64010584-64023458 protein_coding
  ENST00000492933 PSMD6-002 64010555-64023472 protein_coding
  ENST00000497315 PSMD6-010 64018321-64019389 retained_intron
  ENST00000497323 PSMD6-008 64018899-64023458 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000295901ENST00000394431ENST00000467853ENST00000475036ENST00000478185ENST00000480205ENST00000482510ENST00000492933
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000295901 29.959±0.00 22.626±0.00 2.645±0.00 27.812±11.74 16.623±5.93 19.843±7.53 19.006±10.53 19.952±8.70 19.936±6.13 13.246±0.80 17.035±11.66 19.230±8.54 35.198±5.10 73.339±4.55
ENST00000394431 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.604±0.00
ENST00000467853 N/A 2.143±0.00 2.293±0.00 N/A 3.482±0.00 3.161±0.00 N/A N/A 2.556±0.00 4.237±3.34 N/A 2.264±0.50 N/A N/A
ENST00000475036 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 31.344±0.00
ENST00000478185 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 23.789±0.00 37.332±0.00 56.963±0.00
ENST00000480205 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 26.119±0.00
ENST00000482510 N/A 18.311±0.00 6.470±0.00 13.102±0.00 12.973±0.00 N/A 5.916±0.00 9.636±3.13 N/A N/A 9.667±0.00 8.865±2.79 N/A N/A
ENST00000492933 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.874±0.00 4.682±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00079H CIL_00079H_0001 CGP 3:63864557-64024010

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005515 IEA protein binding
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006200 NAS ATP catabolic process
GO:0006508 NAS proteolysis
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016887 NAS ATPase activity
GO:0022624 ISS proteasome accessory complex
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070674 psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 protein_coding Danio_rerio
ENSMUSG00000021737 Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 protein_coding Mus_musculus

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