C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: toll-like receptor 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164342 TLR3 9606 + 4:186069152-186088069 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000296795 TLR3-001 186069152-186088069 protein_coding
  ENST00000504367 TLR3-003 186081617-186084889 protein_coding
  ENST00000508051 TLR3-005 186081619-186082717 processed_transcript
  ENST00000512264 TLR3-004 186081611-186085024 retained_intron
  ENST00000513189 TLR3-002 186069155-186082933 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000296795ENST00000504367ENST00000512264ENST00000513189
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000296795 0.253±0.00 N/A N/A 0.193±0.00 1.344±0.77 0.838±0.37 0.256±0.02 0.840±0.51 0.267±0.05 1.136±0.00 N/A 0.556±0.35 1.260±0.29 N/A
ENST00000504367 0.372±0.00 N/A 0.923±0.00 N/A 1.237±0.23 1.208±0.00 0.134±0.00 1.430±0.25 0.714±0.50 1.672±0.22 0.273±0.00 0.495±0.21 2.780±0.37 1.678±0.93
ENST00000512264 0.339±0.00 0.594±0.00 N/A 0.144±0.00 N/A 0.549±0.00 0.296±0.00 N/A N/A 0.366±0.00 N/A 0.123±0.00 N/A 0.337±0.00
ENST00000513189 N/A N/A N/A 0.803±0.00 1.461±0.00 0.962±0.00 0.332±0.06 2.707±0.00 1.874±0.00 2.930±0.00 0.698±0.00 1.108±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000H1 CIL_0000H1_0002 CGP 4:185585444-186088069

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0001774 IEA microglial cell activation
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002282 IEA microglial cell activation involved in immune response
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0003725 NAS double-stranded RNA binding
GO:0004872 TAS receptor activity
GO:0004888 NAS transmembrane signaling receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005622 IEA intracellular
GO:0005737 IDA cytoplasm
GO:0005765 IDA lysosomal membrane
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006952 IEA defense response
GO:0006954 IEA inflammatory response
GO:0006972 NAS hyperosmotic response
GO:0007165 TAS:IEA signal transduction
GO:0007249 TAS I-kappaB kinase/NF-kappaB signaling
GO:0007250 NAS activation of NF-kappaB-inducing kinase activity
GO:0007252 IDA I-kappaB phosphorylation
GO:0008584 IEA male gonad development
GO:0009597 NAS detection of virus
GO:0009615 IEA response to virus
GO:0009986 IEA cell surface
GO:0010008 TAS endosome membrane
GO:0016020 NAS membrane
GO:0016021 IEA integral component of membrane
GO:0032481 IEA positive regulation of type I interferon production
GO:0032722 IDA positive regulation of chemokine production
GO:0032728 ISS positive regulation of interferon-beta production
GO:0032735 ISS positive regulation of interleukin-12 production
GO:0032755 IDA positive regulation of interleukin-6 production
GO:0032757 IDA positive regulation of interleukin-8 production
GO:0032760 ISS positive regulation of tumor necrosis factor production
GO:0034123 IDA positive regulation of toll-like receptor signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034346 IEA positive regulation of type III interferon production
GO:0035458 IEA cellular response to interferon-beta
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035690 IEA cellular response to drug
GO:0036020 TAS endolysosome membrane
GO:0042346 IDA positive regulation of NF-kappaB import into nucleus
GO:0042742 TAS defense response to bacterium
GO:0043065 IEA positive regulation of apoptotic process
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 IDA response to exogenous dsRNA
GO:0043331 IEA response to dsRNA
GO:0045078 IDA positive regulation of interferon-gamma biosynthetic process
GO:0045080 IEA positive regulation of chemokine biosynthetic process
GO:0045087 TAS innate immune response
GO:0045356 IDA positive regulation of interferon-alpha biosynthetic process
GO:0045359 IMP positive regulation of interferon-beta biosynthetic process
GO:0045671 NAS negative regulation of osteoclast differentiation
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IEA positive regulation of JNK cascade
GO:0050729 IC positive regulation of inflammatory response
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051607 TAS defense response to virus
GO:0071260 IEP cellular response to mechanical stimulus
GO:0071346 IEA cellular response to interferon-gamma
GO:0071359 IEA cellular response to dsRNA
GO:0071360 IEA cellular response to exogenous dsRNA
GO:0097191 IDA extrinsic apoptotic signaling pathway
GO:0097527 IDA necroptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016065 tlr3 toll-like receptor 3 protein_coding Danio_rerio
ENSMUSG00000031639 Tlr3 toll-like receptor 3 protein_coding Mus_musculus

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