C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: telomerase reverse transcriptase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164362 TERT 9606 - 5:1253147-1295069 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000310581 TERT-001 1253167-1295047 protein_coding
  ENST00000334602 TERT-005 1253728-1294989 protein_coding
  ENST00000460137 TERT-004 1253728-1294989 nonsense_mediated_decay
  ENST00000484238 TERT-003 1253147-1283010 retained_intron
  ENST00000503656 TERT-007 1264248-1266524 retained_intron
  ENST00000508104 TERT-006 1266450-1294989 protein_coding
  ENST00000522877 TERT-008 1294558-1295069 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonLiverOvaryTestisENST00000310581ENST00000484238ENST00000503656ENST00000508104
Transcript ID Adipose Adrenal Brain Breast Colon Liver Ovary Testis
ENST00000310581 N/A N/A 0.023±0.00 N/A N/A N/A 0.346±0.26 0.193±0.01
ENST00000484238 N/A 0.036±0.00 N/A N/A 0.105±0.03 N/A N/A N/A
ENST00000503656 N/A N/A N/A N/A 1.183±0.00 N/A 1.678±0.87 2.584±0.00
ENST00000508104 0.046±0.00 N/A N/A 0.125±0.00 N/A 0.083±0.00 0.205±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000723 TAS telomere maintenance
GO:0000781 IC chromosome, telomeric region
GO:0000783 IC nuclear telomere cap complex
GO:0003720 IDA telomerase activity
GO:0003721 TAS telomeric template RNA reverse transcriptase activity
GO:0003964 IEA RNA-directed DNA polymerase activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005654 IDA nucleoplasm
GO:0005697 IDA telomerase holoenzyme complex
GO:0005737 IEA cytoplasm
GO:0007004 IMP telomere maintenance via telomerase
GO:0016605 IDA PML body
GO:0022616 IDA DNA strand elongation
GO:0032203 IDA telomere formation via telomerase
GO:0042162 TAS telomeric DNA binding
GO:0042803 IDA protein homodimerization activity
GO:0046872 IEA metal ion binding
GO:0070034 IDA telomeric RNA binding
GO:0090399 IMP replicative senescence
GO:2001240 IMP negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042637 tert telomerase reverse transcriptase protein_coding Danio_rerio
ENSMUSG00000021611 Tert telomerase reverse transcriptase protein_coding Mus_musculus

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