C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cyclin-dependent kinase 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164885 CDK5 9606 - 7:151053812-151058530 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000297518 CDK5-003 151054009-151057848 protein_coding
  ENST00000469108 CDK5-005 151056566-151057894 retained_intron
  ENST00000476691 CDK5-006 151055489-151056360 retained_intron
  ENST00000485972 CDK5-001 151053812-151058530 protein_coding
  ENST00000487703 CDK5-004 151055299-151057744 retained_intron
  ENST00000618146 CDK5-201 151053812-151057965 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainMuscleOvaryPlacentaTestisENST00000297518ENST00000618146
Transcript ID Brain Muscle Ovary Placenta Testis
ENST00000297518 N/A 3.485±0.00 N/A N/A N/A
ENST00000618146 28.639±9.23 2.485±0.00 15.554±0.00 12.976±0.00 7.002±1.38

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008T1 CIL_0008T1_0001 VISTA 7:150668461-151272977
CIL_0004ET CIL_0004ET_0001 CGP 7:151048292-151058530
CIL_0004ES CIL_0004ES_0001 CGP 7:151053812-151076527

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001764 TAS neuron migration
GO:0001963 IEA synaptic transmission, dopaminergic
GO:0002039 IEA p53 binding
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004693 IEA cyclin-dependent protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005176 ISS ErbB-2 class receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006468 IEA protein phosphorylation
GO:0006886 IEA intracellular protein transport
GO:0006887 IEA exocytosis
GO:0006913 IEA nucleocytoplasmic transport
GO:0006915 IEA apoptotic process
GO:0007049 IEA cell cycle
GO:0007160 IEA cell-matrix adhesion
GO:0007268 TAS synaptic transmission
GO:0007409 IEA axonogenesis
GO:0007411 TAS axon guidance
GO:0007416 TAS synapse assembly
GO:0007519 IEA skeletal muscle tissue development
GO:0007596 TAS blood coagulation
GO:0008045 IEA motor neuron axon guidance
GO:0008092 IEA cytoskeletal protein binding
GO:0008283 TAS cell proliferation
GO:0008306 IEA associative learning
GO:0008542 IEA visual learning
GO:0009611 IEA response to wounding
GO:0009790 ISS embryo development
GO:0014044 IEA Schwann cell development
GO:0014069 ISS postsynaptic density
GO:0016020 ISS membrane
GO:0016079 TAS synaptic vesicle exocytosis
GO:0016301 ISS kinase activity
GO:0016310 IDA phosphorylation
GO:0016477 IEA cell migration
GO:0016533 IEA cyclin-dependent protein kinase 5 holoenzyme complex
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0019233 IEA sensory perception of pain
GO:0021537 IEA telencephalon development
GO:0021549 IEA cerebellum development
GO:0021695 IEA cerebellar cortex development
GO:0021697 IEA cerebellar cortex formation
GO:0021766 IEA hippocampus development
GO:0021819 IEA layer formation in cerebral cortex
GO:0021954 IEA central nervous system neuron development
GO:0021987 IEA cerebral cortex development
GO:0022038 IEA corpus callosum development
GO:0030027 IEA lamellipodium
GO:0030054 IEA cell junction
GO:0030175 IEA filopodium
GO:0030182 ISS neuron differentiation
GO:0030334 IEA regulation of cell migration
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0030426 ISS growth cone
GO:0030517 IEA negative regulation of axon extension
GO:0030549 ISS acetylcholine receptor activator activity
GO:0030866 IEA cortical actin cytoskeleton organization
GO:0030900 IEA forebrain development
GO:0031175 ISS neuron projection development
GO:0031397 IEA negative regulation of protein ubiquitination
GO:0031594 ISS neuromuscular junction
GO:0031914 IEA negative regulation of synaptic plasticity
GO:0032092 IEA positive regulation of protein binding
GO:0032801 IEA receptor catabolic process
GO:0033136 IEA serine phosphorylation of STAT3 protein
GO:0035249 IEA synaptic transmission, glutamatergic
GO:0035418 IEA protein localization to synapse
GO:0036465 NAS synaptic vesicle recycling
GO:0042220 IEA response to cocaine
GO:0042981 TAS regulation of apoptotic process
GO:0043025 ISS neuronal cell body
GO:0043113 IEA receptor clustering
GO:0043125 ISS ErbB-3 class receptor binding
GO:0043525 ISS positive regulation of neuron apoptotic process
GO:0045055 IEA regulated secretory pathway
GO:0045211 IEA postsynaptic membrane
GO:0045786 IEA negative regulation of cell cycle
GO:0045860 IEA positive regulation of protein kinase activity
GO:0045861 IMP negative regulation of proteolysis
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045956 IEA positive regulation of calcium ion-dependent exocytosis
GO:0046777 IEA protein autophosphorylation
GO:0046826 IEA negative regulation of protein export from nucleus
GO:0046875 IEA ephrin receptor binding
GO:0048148 IEA behavioral response to cocaine
GO:0048167 ISS regulation of synaptic plasticity
GO:0048488 TAS synaptic vesicle endocytosis
GO:0048511 IEA rhythmic process
GO:0048675 TAS axon extension
GO:0048709 IDA oligodendrocyte differentiation
GO:0048812 IEA neuron projection morphogenesis
GO:0048813 IEA dendrite morphogenesis
GO:0050321 ISS tau-protein kinase activity
GO:0051301 IEA cell division
GO:0051402 TAS neuron apoptotic process
GO:0060078 IEA regulation of postsynaptic membrane potential
GO:0060079 IEA regulation of excitatory postsynaptic membrane potential
GO:0061001 ISS regulation of dendritic spine morphogenesis
GO:0070509 IEA calcium ion import
GO:0071156 TAS regulation of cell cycle arrest
GO:0090314 IEA positive regulation of protein targeting to membrane
GO:1901215 IDA negative regulation of neuron death
GO:2000251 TAS positive regulation of actin cytoskeleton reorganization
GO:2000273 IEA positive regulation of receptor activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056683 cdk5 cyclin-dependent protein kinase 5 protein_coding Danio_rerio
ENSMUSG00000028969 Cdk5 cyclin-dependent kinase 5 protein_coding Mus_musculus

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