C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tripeptidyl peptidase I
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166340 TPP1 9606 - 11:6612763-6619461 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000299427 TPP1-001 6612763-6619461 protein_coding
  ENST00000428886 TPP1-002 6616990-6619422 retained_intron
  ENST00000436873 TPP1-019 6616423-6619429 protein_coding
  ENST00000524611 TPP1-012 6614646-6615473 processed_transcript
  ENST00000524788 TPP1-015 6616694-6617361 processed_transcript
  ENST00000524903 TPP1-011 6618546-6619381 processed_transcript
  ENST00000524924 TPP1-013 6615262-6616104 processed_transcript
  ENST00000528571 TPP1-017 6616983-6619422 nonsense_mediated_decay
  ENST00000528657 TPP1-008 6618729-6619422 protein_coding
  ENST00000528807 TPP1-018 6616512-6617211 processed_transcript
  ENST00000528917 TPP1-009 6617748-6619421 retained_intron
  ENST00000530040 TPP1-010 6617370-6619396 processed_transcript
  ENST00000531754 TPP1-007 6618443-6619448 retained_intron
  ENST00000532191 TPP1-014 6615216-6615760 processed_transcript
  ENST00000533371 TPP1-003 6612772-6619354 protein_coding
  ENST00000534644 TPP1-016 6617011-6619409 processed_transcript
  ENST00000611494 TPP1-201 6613849-6619430 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000299427ENST00000436873ENST00000530040ENST00000533371ENST00000611494
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000299427 35.863±0.00 34.671±0.00 6.998±0.00 24.040±20.43 15.320±12.07 15.398±12.73 15.115±14.35 22.231±14.86 16.229±14.88 61.865±0.00 13.077±0.00 18.069±12.41 53.723±17.00 25.088±0.00
ENST00000436873 N/A N/A N/A 2.824±0.00 N/A 3.529±0.00 2.833±0.00 N/A N/A N/A 1.566±0.00 N/A N/A N/A
ENST00000530040 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.048±0.00 N/A N/A
ENST00000533371 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.009±0.00 N/A 7.583±0.00 10.360±0.00 5.727±0.00
ENST00000611494 14.667±0.00 N/A N/A N/A 10.714±0.00 14.893±0.00 0.631±0.00 2.247±0.00 N/A 2.364±0.00 N/A 13.145±4.27 39.135±0.00 4.231±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003WX CIL_0003WX_0001 CGP 11:6606296-6619461
CIL_0003WC CIL_0003WC_0001 CGP 11:6612763-6655854

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004175 IMP endopeptidase activity
GO:0004252 IEA serine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005739 IEA mitochondrion
GO:0005764 IDA lysosome
GO:0006508 IMP:IEA proteolysis
GO:0006629 TAS lipid metabolic process
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0007040 ISS lysosome organization
GO:0007399 IMP nervous system development
GO:0008219 IEA cell death
GO:0008233 IMP peptidase activity
GO:0008236 IMP:IEA serine-type peptidase activity
GO:0008240 IMP tripeptidyl-peptidase activity
GO:0030163 NAS protein catabolic process
GO:0030855 IEP epithelial cell differentiation
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0042277 ISS peptide binding
GO:0043171 IMP peptide catabolic process
GO:0043202 TAS lysosomal lumen
GO:0044267 TAS cellular protein metabolic process
GO:0045453 IMP bone resorption
GO:0046872 IEA metal ion binding
GO:0050885 ISS neuromuscular process controlling balance
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042793 tpp1 tripeptidyl peptidase I protein_coding Danio_rerio
ENSMUSG00000030894 Tpp1 tripeptidyl peptidase I protein_coding Mus_musculus

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