C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166484 MAPK7 9606 + 17:19377721-19383544 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000299612 MAPK7-003 19377753-19383544 protein_coding
  ENST00000308406 MAPK7-201 19377721-19383543 protein_coding
  ENST00000395602 MAPK7-001 19378253-19383544 protein_coding
  ENST00000395604 MAPK7-002 19378323-19383544 protein_coding
  ENST00000443215 MAPK7-005 19378282-19380933 protein_coding
  ENST00000482850 MAPK7-004 19378509-19381213 protein_coding
  ENST00000486905 MAPK7-006 19378555-19380083 retained_intron
  ENST00000490660 MAPK7-008 19378892-19383544 retained_intron
  ENST00000570306 MAPK7-007 19378529-19383538 retained_intron
  ENST00000571657 MAPK7-009 19377799-19383339 processed_transcript
  ENST00000572716 MAPK7-014 19380232-19381113 retained_intron
  ENST00000572853 MAPK7-013 19378749-19379961 retained_intron
  ENST00000572968 MAPK7-011 19378468-19380472 processed_transcript
  ENST00000573417 MAPK7-010 19377992-19382088 processed_transcript
  ENST00000573466 MAPK7-012 19378504-19380166 retained_intron
  ENST00000579284 MAPK7-015 19378260-19380680 protein_coding
  ENST00000581260 MAPK7-016 19378527-19380860 nonsense_mediated_decay
  ENST00000603493 MAPK7-018 19378751-19380623 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainLiverMuscleOvaryENST00000395604ENST00000490660
Transcript ID Adipose Brain Liver Muscle Ovary
ENST00000395604 4.780±0.00 N/A N/A 2.029±0.00 N/A
ENST00000490660 4.533±0.00 2.516±0.00 1.446±0.00 N/A 2.879±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00077E CIL_00077E_0002 CGP 17:19215615-19378182

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004707 IEA MAP kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006468 IEA protein phosphorylation
GO:0007049 IEA cell cycle
GO:0007165 TAS signal transduction
GO:0008152 IEA metabolic process
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0016020 IEA membrane
GO:0016605 IDA PML body
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0019933 NAS cAMP-mediated signaling
GO:0030154 IEA cell differentiation
GO:0030821 NAS negative regulation of cAMP catabolic process
GO:0034115 IGI negative regulation of heterotypic cell-cell adhesion
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0036003 IMP positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043066 IEA negative regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0045765 IEA regulation of angiogenesis
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050728 TAS negative regulation of inflammatory response
GO:0051019 IPI mitogen-activated protein kinase binding
GO:0051247 IGI positive regulation of protein metabolic process
GO:0051344 NAS negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051403 TAS stress-activated MAPK cascade
GO:0051534 IEA negative regulation of NFAT protein import into nucleus
GO:0060761 IGI negative regulation of response to cytokine stimulus
GO:0070301 IMP cellular response to hydrogen peroxide
GO:0071363 IGI cellular response to growth factor stimulus
GO:0071499 TAS cellular response to laminar fluid shear stress
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:1902176 IMP negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000352 IMP negative regulation of endothelial cell apoptotic process
GO:2001240 IGI negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000023110 mapk7 mitogen-activated protein kinase 7 protein_coding Danio_rerio
ENSMUSG00000001034 Mapk7 mitogen-activated protein kinase 7 protein_coding Mus_musculus

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