C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mesoderm posterior basic helix-loop-helix transcription factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166823 MESP1 9606 - 15:89748661-89751310 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000300057 MESP1-001 89748661-89751310 protein_coding
  ENST00000559894 MESP1-002 89749891-89751137 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000300057ENST00000559894
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000300057 0.559±0.00 0.011±0.00 0.688±0.18 0.962±0.87 0.193±0.07 0.169±0.13 0.153±0.00 0.088±0.00 0.019±0.00 0.414±0.00 0.080±0.05 0.092±0.05 0.424±0.31
ENST00000559894 4.586±0.00 0.665±0.00 6.402±0.00 12.532±0.00 1.023±0.77 1.901±0.00 0.783±0.00 1.576±0.00 0.434±0.00 1.013±0.56 1.754±1.04 0.713±0.15 5.506±3.83

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00052Y CIL_00052Y_0001 CGP 15:89690797-89751310
CIL_0002RA CIL_0002RA_0003 CGP 15:89748661-89778754

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001947 ISS heart looping
GO:0003007 IEA heart morphogenesis
GO:0003139 ISS secondary heart field specification
GO:0003143 ISS embryonic heart tube morphogenesis
GO:0003210 IMP cardiac atrium formation
GO:0003211 IMP cardiac ventricle formation
GO:0003236 ISS sinus venosus morphogenesis
GO:0003241 ISS growth involved in heart morphogenesis
GO:0003259 ISS cardioblast anterior-lateral migration
GO:0003260 IEA cardioblast migration
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005634 IC nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0007219 IEA Notch signaling pathway
GO:0007369 ISS gastrulation
GO:0008078 IEA mesodermal cell migration
GO:0022008 IMP neurogenesis
GO:0023019 IEA signal transduction involved in regulation of gene expression
GO:0035326 IEA enhancer binding
GO:0035481 IEA positive regulation of Notch signaling pathway involved in heart induction
GO:0042662 ISS negative regulation of mesodermal cell fate specification
GO:0042664 ISS negative regulation of endodermal cell fate specification
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045446 IMP endothelial cell differentiation
GO:0045747 ISS positive regulation of Notch signaling pathway
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IEA protein dimerization activity
GO:0048368 ISS lateral mesoderm development
GO:0051155 ISS positive regulation of striated muscle cell differentiation
GO:0055007 IMP cardiac muscle cell differentiation
GO:0060913 ISS cardiac cell fate determination
GO:0060921 IMP sinoatrial node cell differentiation
GO:0060947 IMP cardiac vascular smooth muscle cell differentiation
GO:0060975 ISS cardioblast migration to the midline involved in heart field formation
GO:0070368 ISS positive regulation of hepatocyte differentiation
GO:0090082 ISS positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017078 mespaa mesoderm posterior aa protein_coding Danio_rerio
ENSDARG00000030347 mespba mesoderm posterior ba protein_coding Danio_rerio
ENSDARG00000068761 mespab mesoderm posterior ab protein_coding Danio_rerio
ENSDARG00000087219 BX572619.4 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000097947 mespbb mesoderm posterior bb protein_coding Danio_rerio
ENSMUSG00000030544 Mesp1 mesoderm posterior 1 protein_coding Mus_musculus

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