C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Fas (TNFRSF6)-associated via death domain
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168040 FADD 9606 + 11:70203163-70207390 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000301838 FADD-001 70203163-70207390 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000301838
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000301838 3.078±0.00 3.960±0.00 0.810±0.00 1.656±0.07 2.773±0.77 2.535±0.14 0.914±0.15 2.682±2.19 2.009±0.16 1.791±0.06 0.708±0.11 7.471±6.13 13.958±11.72 3.184±0.61

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000SL CIL_0000SL_0002 CGP 11:70078302-70207390

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001916 ISS positive regulation of T cell mediated cytotoxicity
GO:0002020 IPI protease binding
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0002821 ISS positive regulation of adaptive immune response
GO:0005123 TAS death receptor binding
GO:0005164 IEA tumor necrosis factor receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005737 IEA cytoplasm
GO:0005829 IDA cytosol
GO:0006915 IMP apoptotic process
GO:0006919 TAS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 IEA signal transduction
GO:0008625 TAS extrinsic apoptotic signaling pathway via death domain receptors
GO:0016032 IEA viral process
GO:0031264 IDA death-inducing signaling complex
GO:0031265 IDA CD95 death-inducing signaling complex
GO:0032403 IEA protein complex binding
GO:0032729 ISS positive regulation of interferon-gamma production
GO:0032757 IDA positive regulation of interleukin-8 production
GO:0032760 IDA positive regulation of tumor necrosis factor production
GO:0032813 IPI tumor necrosis factor receptor superfamily binding
GO:0033077 ISS T cell differentiation in thymus
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035877 IPI death effector domain binding
GO:0036462 IDA TRAIL-activated apoptotic signaling pathway
GO:0042104 ISS positive regulation of activated T cell proliferation
GO:0042802 IPI identical protein binding
GO:0042981 IEA regulation of apoptotic process
GO:0043005 IEA neuron projection
GO:0043029 ISS T cell homeostasis
GO:0043065 IMP positive regulation of apoptotic process
GO:0043123 IEP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IEA protein complex
GO:0044297 IEA cell body
GO:0045087 TAS innate immune response
GO:0045121 IEA membrane raft
GO:0045651 IMP positive regulation of macrophage differentiation
GO:0045862 IDA positive regulation of proteolysis
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048535 ISS lymph node development
GO:0048536 ISS spleen development
GO:0048538 ISS thymus development
GO:0051291 IEA protein heterooligomerization
GO:0051607 IMP defense response to virus
GO:0060340 IMP positive regulation of type I interferon-mediated signaling pathway
GO:0060546 IEA negative regulation of necroptotic process
GO:0070236 ISS negative regulation of activation-induced cell death of T cells
GO:0071260 IEP cellular response to mechanical stimulus
GO:0097049 IEA motor neuron apoptotic process
GO:0097190 IDA apoptotic signaling pathway
GO:0097191 IMP extrinsic apoptotic signaling pathway
GO:0097192 IEA extrinsic apoptotic signaling pathway in absence of ligand
GO:0097202 IDA activation of cysteine-type endopeptidase activity
GO:0097342 IDA ripoptosome
GO:0097527 IMP necroptotic signaling pathway
GO:1902043 IEA positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000454 ISS positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001238 IMP positive regulation of extrinsic apoptotic signaling pathway
GO:2001239 TAS regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068099 fadd Fas (tnfrsf6)-associated via death domain protein_coding Danio_rerio
ENSMUSG00000031077 Fadd Fas (TNFRSF6)-associated via death domain protein_coding Mus_musculus

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