C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Fas (TNFRSF6)-associated via death domain
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031077 Fadd 10090 - 7:144577318-144582463 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033394 Fadd-001 144577318-144582463 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033394
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033394 6.202±0.43 10.453±0.78 3.642±0.12 1.408±0.92 7.240±0.38 9.686±0.32 4.977±0.75 7.240±0.74 3.928±1.18 6.030±0.34 0.777±0.08 9.169±3.06 3.022±0.39 1.589±0.39

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001916 IMP positive regulation of T cell mediated cytotoxicity
GO:0002020 IEA protease binding
GO:0002821 IMP positive regulation of adaptive immune response
GO:0005123 IEA death receptor binding
GO:0005164 IEA tumor necrosis factor receptor binding
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005829 IEA cytosol
GO:0006915 ISS apoptotic process
GO:0030217 TAS T cell differentiation
GO:0031264 IEA death-inducing signaling complex
GO:0031265 IEA CD95 death-inducing signaling complex
GO:0032403 IEA protein complex binding
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0032757 IEA positive regulation of interleukin-8 production
GO:0032760 IEA positive regulation of tumor necrosis factor production
GO:0032813 IEA tumor necrosis factor receptor superfamily binding
GO:0033077 IMP T cell differentiation in thymus
GO:0035877 IEA death effector domain binding
GO:0036462 IEA TRAIL-activated apoptotic signaling pathway
GO:0042104 IMP positive regulation of activated T cell proliferation
GO:0042802 IEA identical protein binding
GO:0043005 IEA neuron projection
GO:0043029 IMP T cell homeostasis
GO:0043065 IEA positive regulation of apoptotic process
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IEA protein complex
GO:0044297 IEA cell body
GO:0045087 TAS innate immune response
GO:0045121 IEA membrane raft
GO:0045651 IEA positive regulation of macrophage differentiation
GO:0045862 IEA positive regulation of proteolysis
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048535 IGI lymph node development
GO:0048536 IGI spleen development
GO:0048538 IGI thymus development
GO:0048738 TAS cardiac muscle tissue development
GO:0051291 IEA protein heterooligomerization
GO:0051607 IEA defense response to virus
GO:0060340 IEA positive regulation of type I interferon-mediated signaling pathway
GO:0060546 IGI negative regulation of necroptotic process
GO:0070236 IMP negative regulation of activation-induced cell death of T cells
GO:0071260 IEA cellular response to mechanical stimulus
GO:0097049 IMP motor neuron apoptotic process
GO:0097190 IEA apoptotic signaling pathway
GO:0097191 IDA extrinsic apoptotic signaling pathway
GO:0097192 IMP extrinsic apoptotic signaling pathway in absence of ligand
GO:0097202 IEA activation of cysteine-type endopeptidase activity
GO:0097342 ISS ripoptosome
GO:0097527 IEA necroptotic signaling pathway
GO:1902043 IGI positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000454 IMP positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001238 IGI positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068099 fadd Fas (tnfrsf6)-associated via death domain protein_coding Danio_rerio
ENSG00000168040 FADD Fas (TNFRSF6)-associated via death domain protein_coding Homo_sapiens

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