C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DNA-damage-inducible transcript 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168209 DDIT4 9606 + 10:72273920-72276036 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000307365 DDIT4-001 72273920-72276036 protein_coding
  ENST00000471240 DDIT4-003 72274019-72274635 retained_intron
  ENST00000473155 DDIT4-002 72273925-72274950 retained_intron

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000307365ENST00000473155
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000307365 58.287±0.00 48.593±0.00 N/A 6.700±4.58 7.387±4.60 27.856±27.29 5.921±4.63 11.293±10.74 8.744±1.82 20.405±12.04 18.828±12.72 31.454±13.19 15.848±6.92 12.278±7.43
ENST00000473155 N/A N/A 3.007±0.00 N/A N/A N/A 11.876±10.28 33.614±0.00 11.105±0.00 73.625±0.00 62.099±0.00 94.677±28.50 25.510±7.92 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007VS CIL_0007VS_0001 VISTA 10:71953326-72556599
CIL_0000Q3 CIL_0000Q3_0002 CGP 10:72216000-72276036
CIL_0000Q2 CIL_0000Q2_0002 CGP 10:72273920-72355230

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IDA response to hypoxia
GO:0001764 ISS neuron migration
GO:0005622 IDA intracellular
GO:0005737 IDA:IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0007420 ISS brain development
GO:0008283 ISS cell proliferation
GO:0009968 IEA negative regulation of signal transduction
GO:0010801 ISS negative regulation of peptidyl-threonine phosphorylation
GO:0030182 ISS neuron differentiation
GO:0032007 IMP negative regulation of TOR signaling
GO:0033137 ISS negative regulation of peptidyl-serine phosphorylation
GO:0042771 ISS intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043241 IEA protein complex disassembly
GO:0045820 IEA negative regulation of glycolytic process
GO:0048011 ISS neurotrophin TRK receptor signaling pathway
GO:0051607 IEA defense response to virus
GO:0071889 IEA 14-3-3 protein binding
GO:0072593 IEA reactive oxygen species metabolic process
GO:1901216 ISS positive regulation of neuron death
GO:1902532 ISS negative regulation of intracellular signal transduction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037618 ddit4 DNA-damage-inducible transcript 4 protein_coding Danio_rerio
ENSMUSG00000020108 Ddit4 DNA-damage-inducible transcript 4 protein_coding Mus_musculus

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