C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169032 MAP2K1 9606 + 15:66386817-66492312 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000307102 MAP2K1-001 66386817-66492312 protein_coding
  ENST00000425818 MAP2K1-002 66386837-66444966 retained_intron
  ENST00000566326 MAP2K1-003 66453454-66491343 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000307102ENST00000425818ENST00000566326
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000307102 8.472±0.00 7.417±0.00 1.410±0.00 19.062±5.46 14.316±0.00 5.401±2.74 3.682±2.83 9.103±3.39 3.789±2.22 1.641±0.00 6.490±0.00 8.028±0.63 6.964±0.65 6.575±0.00
ENST00000425818 N/A N/A 2.526±0.00 N/A 6.676±0.00 3.277±0.00 2.502±0.00 N/A 5.730±0.00 14.662±7.83 8.386±0.00 24.233±18.86 32.688±0.00 16.623±0.00
ENST00000566326 20.417±0.00 16.893±0.00 N/A 43.445±0.00 18.181±11.92 16.509±0.00 14.618±0.00 20.569±0.00 7.686±4.80 16.841±0.00 14.418±0.00 23.553±20.19 40.065±0.00 18.673±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008Q7 CIL_0008Q7_0001 VISTA 15:66378983-66980203

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 TAS MAPK cascade
GO:0000186 TAS activation of MAPKK activity
GO:0000187 TAS activation of MAPK activity
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0003056 IEA regulation of vascular smooth muscle contraction
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 TAS protein serine/threonine kinase activity
GO:0004708 IDA MAP kinase kinase activity
GO:0004712 TAS protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004728 IEA receptor signaling protein tyrosine phosphatase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 TAS nucleus
GO:0005737 IDA cytoplasm
GO:0005739 TAS mitochondrion
GO:0005769 TAS early endosome
GO:0005770 TAS late endosome
GO:0005794 TAS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005874 IEA microtubule
GO:0005886 IDA plasma membrane
GO:0005925 TAS focal adhesion
GO:0005938 IEA cell cortex
GO:0006468 IEA protein phosphorylation
GO:0006928 TAS cellular component movement
GO:0006935 TAS chemotaxis
GO:0006979 IEA response to oxidative stress
GO:0007050 IMP cell cycle arrest
GO:0007067 IEA mitotic nuclear division
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007411 TAS axon guidance
GO:0008283 IEA cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010628 IMP positive regulation of gene expression
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017016 IEA Ras GTPase binding
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0030182 IEA neuron differentiation
GO:0030216 IEA keratinocyte differentiation
GO:0030335 IEA positive regulation of cell migration
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0032320 IEA positive regulation of Ras GTPase activity
GO:0032402 IEA melanosome transport
GO:0032839 IEA dendrite cytoplasm
GO:0032872 TAS regulation of stress-activated MAPK cascade
GO:0032968 IEA positive regulation of transcription elongation from RNA polymerase II promoter
GO:0034111 IEA negative regulation of homotypic cell-cell adhesion
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043204 IEA perikaryon
GO:0043539 IDA protein serine/threonine kinase activator activity
GO:0045087 TAS innate immune response
GO:0045597 IEA positive regulation of cell differentiation
GO:0046579 IEA positive regulation of Ras protein signal transduction
GO:0047496 IEA vesicle transport along microtubule
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048313 IEA Golgi inheritance
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048678 IEA response to axon injury
GO:0048812 IEA neuron projection morphogenesis
GO:0048870 IEA cell motility
GO:0051291 IEA protein heterooligomerization
GO:0051384 IEA response to glucocorticoid
GO:0051403 TAS stress-activated MAPK cascade
GO:0060674 IEA placenta blood vessel development
GO:0060711 IEA labyrinthine layer development
GO:0070062 IDA extracellular vesicular exosome
GO:0071902 IDA positive regulation of protein serine/threonine kinase activity
GO:0090170 TAS regulation of Golgi inheritance
GO:0090398 IMP cellular senescence
GO:2000641 TAS regulation of early endosome to late endosome transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007825 map2k1 mitogen-activated protein kinase kinase 1 protein_coding Danio_rerio
ENSMUSG00000004936 Map2k1 mitogen-activated protein kinase kinase 1 protein_coding Mus_musculus

Loading