C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000004936 Map2k1 10090 - 9:64185770-64253631 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000005066 Map2k1-001 64185770-64253631 protein_coding
  ENSMUST00000147796 Map2k1-002 64186529-64187864 retained_intron
  ENSMUST00000152535 Map2k1-004 64187289-64195678 processed_transcript
  ENSMUST00000152675 Map2k1-003 64186737-64188256 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000005066ENSMUST00000152535
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000005066 15.595±2.33 20.923±3.49 23.096±7.35 35.699±34.28 16.199±4.00 50.697±12.73 9.190±0.51 13.668±1.15 13.270±2.31 20.945±2.55 17.442±2.06 25.216±5.83 55.109±12.35 2.608±0.06
ENSMUST00000152535 N/A N/A N/A 81.220±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 63.163±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008Q7 CIL_0008Q7_0002 VISTA 9:63744784-64346949

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000187 IMP activation of MAPK activity
GO:0003056 IEA regulation of vascular smooth muscle contraction
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IMP MAP kinase kinase activity
GO:0004712 TAS protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004728 IMP receptor signaling protein tyrosine phosphatase activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005737 IEA cytoplasm
GO:0005739 TAS mitochondrion
GO:0005769 TAS early endosome
GO:0005770 TAS late endosome
GO:0005794 TAS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005874 IEA microtubule
GO:0005886 IEA plasma membrane
GO:0005925 TAS focal adhesion
GO:0005938 IEA cell cortex
GO:0006468 IMP protein phosphorylation
GO:0006979 IEA response to oxidative stress
GO:0007050 IEA cell cycle arrest
GO:0007067 IEA mitotic nuclear division
GO:0008283 IEA cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0010628 IEA positive regulation of gene expression
GO:0017016 IEA Ras GTPase binding
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0030182 IMP neuron differentiation
GO:0030216 IMP keratinocyte differentiation
GO:0030335 IEA positive regulation of cell migration
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0032320 IEA positive regulation of Ras GTPase activity
GO:0032402 IEA melanosome transport
GO:0032839 IEA dendrite cytoplasm
GO:0032872 TAS regulation of stress-activated MAPK cascade
GO:0032968 IEA positive regulation of transcription elongation from RNA polymerase II promoter
GO:0034111 IEA negative regulation of homotypic cell-cell adhesion
GO:0043204 IEA perikaryon
GO:0043539 IEA protein serine/threonine kinase activator activity
GO:0045597 IDA positive regulation of cell differentiation
GO:0046579 ISO positive regulation of Ras protein signal transduction
GO:0047496 IEA vesicle transport along microtubule
GO:0048313 IEA Golgi inheritance
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048678 IEA response to axon injury
GO:0048812 IEA neuron projection morphogenesis
GO:0048870 IMP cell motility
GO:0051291 IEA protein heterooligomerization
GO:0051384 IEA response to glucocorticoid
GO:0060674 IMP placenta blood vessel development
GO:0060711 IMP labyrinthine layer development
GO:0070062 IEA extracellular vesicular exosome
GO:0071902 IEA positive regulation of protein serine/threonine kinase activity
GO:0090170 TAS regulation of Golgi inheritance
GO:0090398 IEA cellular senescence
GO:2000641 TAS regulation of early endosome to late endosome transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007825 map2k1 mitogen-activated protein kinase kinase 1 protein_coding Danio_rerio
ENSG00000169032 MAP2K1 mitogen-activated protein kinase kinase 1 protein_coding Homo_sapiens

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