C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fatty acid synthase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169710 FASN 9606 - 17:82078338-82098332 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000306749 FASN-001 82078338-82098332 protein_coding
  ENST00000578424 FASN-004 82079531-82081370 retained_intron
  ENST00000579410 FASN-003 82085158-82085660 retained_intron
  ENST00000579758 FASN-007 82079360-82083297 processed_transcript
  ENST00000580382 FASN-005 82079168-82080742 nonsense_mediated_decay
  ENST00000584610 FASN-006 82078602-82079929 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000306749ENST00000578424ENST00000579758
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000306749 86.962±0.00 8.068±0.00 1.144±0.00 14.669±9.70 137.134±134.94 10.311±3.51 1.387±0.95 18.137±12.56 22.045±3.46 11.431±5.15 2.744±2.16 19.181±17.92 20.009±4.86 7.699±3.88
ENST00000578424 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 11.087±0.00
ENST00000579758 162.239±0.00 15.755±0.00 N/A 50.170±0.00 438.635±0.00 12.632±0.00 N/A N/A N/A N/A N/A N/A N/A 19.103±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004VI CIL_0004VI_0001 CGP 17:82057506-82098332
CIL_00043S CIL_00043S_0002 CGP 17:82078338-82212830

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001649 IDA osteoblast differentiation
GO:0003824 IEA catalytic activity
GO:0004312 TAS fatty acid synthase activity
GO:0004313 IEA [acyl-carrier-protein] S-acetyltransferase activity
GO:0004314 IEA [acyl-carrier-protein] S-malonyltransferase activity
GO:0004315 IEA 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0004316 IEA 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0004317 IEA 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
GO:0004319 IEA enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
GO:0004320 IEA oleoyl-[acyl-carrier-protein] hydrolase activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005794 IDA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006084 IEA acetyl-CoA metabolic process
GO:0006112 TAS energy reserve metabolic process
GO:0006631 TAS fatty acid metabolic process
GO:0006633 IEA fatty acid biosynthetic process
GO:0006766 TAS vitamin metabolic process
GO:0006767 TAS water-soluble vitamin metabolic process
GO:0008144 IEA drug binding
GO:0008152 IEA metabolic process
GO:0008168 IEA methyltransferase activity
GO:0008270 IEA zinc ion binding
GO:0009058 IEA biosynthetic process
GO:0015939 TAS pantothenate metabolic process
GO:0016020 IDA membrane
GO:0016295 IEA myristoyl-[acyl-carrier-protein] hydrolase activity
GO:0016296 IEA palmitoyl-[acyl-carrier-protein] hydrolase activity
GO:0016491 IEA oxidoreductase activity
GO:0016747 IEA transferase activity, transferring acyl groups other than amino-acyl groups
GO:0016788 IEA hydrolase activity, acting on ester bonds
GO:0019432 TAS triglyceride biosynthetic process
GO:0031177 IEA phosphopantetheine binding
GO:0031325 TAS positive regulation of cellular metabolic process
GO:0035338 TAS long-chain fatty-acyl-CoA biosynthetic process
GO:0042587 IEA glycogen granule
GO:0042802 IEA identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0047117 IEA enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
GO:0047451 IEA 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO:0055114 IEA oxidation-reduction process
GO:0070062 IDA extracellular vesicular exosome
GO:0070402 IEA NADPH binding
GO:0071353 IEA cellular response to interleukin-4

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078895 fasn fatty acid synthase protein_coding Danio_rerio
ENSDARG00000087657 fasn fatty acid synthase protein_coding Danio_rerio
ENSMUSG00000025153 Fasn fatty acid synthase protein_coding Mus_musculus

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