C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fibrinogen alpha chain
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171560 FGA 9606 - 4:154583126-154590766 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302053 FGA-002 154583126-154590766 protein_coding
  ENST00000403106 FGA-001 154585260-154590766 protein_coding
  ENST00000622532 FGA-201 154585281-154590744 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000302053ENST00000403106ENST00000622532
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000302053 N/A N/A 0.096±0.00 0.025±0.02 0.347±0.34 0.005±0.00 0.022±0.00 143.510±140.45 N/A N/A 0.009±0.00 0.048±0.01 0.280±0.01 0.113±0.03
ENST00000403106 0.097±0.00 0.076±0.00 0.298±0.00 0.162±0.13 2.884±2.84 0.056±0.00 0.073±0.00 1375.122±1334.93 0.387±0.00 3.477±3.08 0.242±0.23 0.301±0.05 1.700±0.83 1.294±0.00
ENST00000622532 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.253±0.22 0.049±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008D1 CIL_0008D1_0001 VISTA 4:154359551-154960904
CIL_0000OG CIL_0000OG_0002 CGP 4:154562956-154590766

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002576 TAS platelet degranulation
GO:0005102 IDA:IEA receptor binding
GO:0005198 IMP structural molecule activity
GO:0005515 IPI protein binding
GO:0005576 NAS extracellular region
GO:0005577 IDA:IEA fibrinogen complex
GO:0005615 IDA extracellular space
GO:0005886 TAS plasma membrane
GO:0005938 IEA cell cortex
GO:0007160 IDA cell-matrix adhesion
GO:0007165 IEA signal transduction
GO:0007596 TAS blood coagulation
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0030168 TAS:IEA platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030674 IEA protein binding, bridging
GO:0031091 IDA platelet alpha granule
GO:0031093 TAS platelet alpha granule lumen
GO:0031982 IDA vesicle
GO:0034116 IDA positive regulation of heterotypic cell-cell adhesion
GO:0043623 IDA cellular protein complex assembly
GO:0045907 IDA positive regulation of vasoconstriction
GO:0045921 IDA positive regulation of exocytosis
GO:0050714 IDA positive regulation of protein secretion
GO:0050839 IDA cell adhesion molecule binding
GO:0051258 IDA:IEA protein polymerization
GO:0051592 IDA response to calcium ion
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0070527 IMP platelet aggregation
GO:0072377 IMP blood coagulation, common pathway
GO:0072562 IDA blood microparticle
GO:0090277 IDA positive regulation of peptide hormone secretion
GO:1900026 NAS positive regulation of substrate adhesion-dependent cell spreading
GO:1902042 IDA negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000261 TAS negative regulation of blood coagulation, common pathway
GO:2000352 IDA negative regulation of endothelial cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020741 fga fibrinogen alpha chain protein_coding Danio_rerio
ENSMUSG00000028001 Fga fibrinogen alpha chain protein_coding Mus_musculus

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