C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fibrinogen beta chain
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171564 FGB 9606 + 4:154562956-154571086 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302068 FGB-001 154562956-154571086 protein_coding
  ENST00000425838 FGB-003 154563017-154567615 nonsense_mediated_decay
  ENST00000473984 FGB-005 154565781-154567854 retained_intron
  ENST00000497097 FGB-004 154563012-154566749 retained_intron
  ENST00000498375 FGB-002 154563011-154566522 retained_intron
  ENST00000502545 FGB-011 154563038-154570799 processed_transcript
  ENST00000509493 FGB-010 154563026-154570721 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000302068ENST00000425838ENST00000473984ENST00000497097ENST00000498375ENST00000502545ENST00000509493
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000302068 0.044±0.00 N/A 2.847±0.00 0.120±0.10 4.198±0.00 0.020±0.00 0.081±0.00 927.795±878.91 0.128±0.00 N/A N/A 0.156±0.14 0.457±0.23 0.151±0.00
ENST00000425838 N/A N/A N/A 0.317±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000473984 N/A 0.047±0.00 N/A N/A N/A N/A N/A N/A 0.312±0.00 0.215±0.00 0.109±0.00 N/A N/A N/A
ENST00000497097 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.349±0.00 N/A N/A
ENST00000498375 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.108±0.00
ENST00000502545 N/A N/A 2.198±0.00 N/A 0.087±0.00 N/A 0.051±0.00 N/A 0.078±0.00 0.184±0.00 0.034±0.00 0.079±0.04 0.574±0.00 N/A
ENST00000509493 N/A 0.117±0.00 N/A 0.159±0.08 N/A 0.067±0.04 0.094±0.00 75.006±0.00 N/A 0.307±0.13 0.109±0.10 0.227±0.20 0.308±0.04 0.102±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008D1 CIL_0008D1_0001 VISTA 4:154359551-154960904
CIL_0000OG CIL_0000OG_0002 CGP 4:154562956-154590766

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002576 TAS platelet degranulation
GO:0005102 IDA:IEA receptor binding
GO:0005198 IDA structural molecule activity
GO:0005515 IPI protein binding
GO:0005576 NAS extracellular region
GO:0005577 IDA:IEA fibrinogen complex
GO:0005615 IDA extracellular space
GO:0005737 IEA cytoplasm
GO:0005886 TAS plasma membrane
GO:0005938 IEA cell cortex
GO:0007160 IDA cell-matrix adhesion
GO:0007165 IEA signal transduction
GO:0007596 TAS blood coagulation
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0030168 TAS:IEA platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030674 IEA protein binding, bridging
GO:0031091 IDA platelet alpha granule
GO:0031093 TAS platelet alpha granule lumen
GO:0031982 IDA vesicle
GO:0034116 IDA positive regulation of heterotypic cell-cell adhesion
GO:0043623 IDA cellular protein complex assembly
GO:0044320 IEA cellular response to leptin stimulus
GO:0045907 IDA positive regulation of vasoconstriction
GO:0045921 IDA positive regulation of exocytosis
GO:0050714 IDA positive regulation of protein secretion
GO:0050839 IDA cell adhesion molecule binding
GO:0051087 IPI chaperone binding
GO:0051258 IDA:IEA protein polymerization
GO:0051592 IDA response to calcium ion
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0070527 IDA platelet aggregation
GO:0071347 IEA cellular response to interleukin-1
GO:0072562 IDA blood microparticle
GO:0090277 IDA positive regulation of peptide hormone secretion
GO:1900026 NAS positive regulation of substrate adhesion-dependent cell spreading
GO:1902042 IDA negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352 IDA negative regulation of endothelial cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008969 fgb fibrinogen, B beta polypeptide protein_coding Danio_rerio
ENSMUSG00000033831 Fgb fibrinogen beta chain protein_coding Mus_musculus

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